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首页> 外文期刊>Advanced Functional Materials >Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation
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Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation

机译：姜黄素的超分子纳米纤维对结直肠癌对电离辐射的高度放大放射敏感性

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摘要

Development of highly efficient radiosensitizers is urgently desirable for addressing the resistance of cancer cells to ionizing radiation, which is the main reason for the failure of radiotherapy. Here, it is reported for the first time that supramolecular nanomaterials can serve as an excellent nanoplatform for developing superior radiosensitizers. A new curcumin-based supramolecular nanofiber (Cur-SNF) by virtue of a self-assembling short peptide is developed, which greatly boosts the radiosensitivity of colorectal cancers to ionizing radiation. The drug-peptide conjugate Curcumin-FFE-CS-EE is synthesized and can self-assemble into small-molecule hydrogel containing CurSNFs triggered by reductant. In vitro and in vivo radiosensitization studies reveal that as compared to free curcumin Cur-SNFs show much better performance as a radiosensitizer to sensitize colorectal cancer cells to ionizing radiation thanks to the supramolecular nanostructure. Due to the exceptionally high radiosensitization efficacy, Cur-SNFs in combination with radiation realize significant reduction in tumor volume in vivo. Besides, the molecular mechanism studies demonstrate that Cur-SNFs promote the radiosensitivity of colorectal cancer cells through inhibiting radiation-induced nuclear factor kappa B activation. Cur-SNF achieves an ultralarge sensitizer enhancement ratio at 10% cell survival value of 2.01, the highest among currently reported curcumin-based radiosensitizers.
机译：迫切需要开发高效的放射增敏剂，以解决癌细胞对电离辐射的抵抗力，这是放射疗法失败的主要原因。在这里，首次报道超分子纳米材料可以用作开发优良的放射增敏剂的优良纳米平台。通过自组装短肽，开发了一种新的基于姜黄素的超分子纳米纤维（Cur-SNF），极大地提高了结直肠癌对电离辐射的放射敏感性。合成了药物-肽结合物姜黄素-FFE-CS-EE，它可以自组装成包含由还原剂触发的CurSNF的小分子水凝胶。体外和体内放射增敏研究表明，与游离姜黄素相比，Cur-SNFs具有超敏的性能，因为它具有超分子纳米结构，因此可以使大肠癌细胞对电离辐射敏感。由于异常高的放射增敏功效，Cur-SNF与放射线结合可显着减少体内肿瘤的体积。此外，分子机制研究表明，Cur-SNFs通过抑制辐射诱导的核因子κB活化来促进大肠癌细胞的放射敏感性。 Cur-SNF在10％的细胞存活值为2.01时实现了超大的增敏剂增强率，这是目前报道的基于姜黄素的放射增敏剂中最高的。

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  • 来源
    《Advanced Functional Materials》 |2018年第14期|1707140.1-1707140.11|共11页
  • 作者

    Xu Huae; Wang Tingting; Yang Chengbiao; Li Xiaolin; Liu Guan; Yang Zhimou; Singh Pankaj Kumar; Krishnan Sunil; Ding Dan;

  • 作者单位

    Nanjing Med Univ, Affiliated Hosp 1, Dept Expt Radiat Oncol, Houston, TX 77030 USA;

    Nanjing Univ, Med Sch, State Key Lab Pharmaceut Biotechnol, Div Immunol, Nanjing 210093, Jiangsu, Peoples R China;

    Nankai Univ, Minist Educ, Key Lab Bioact Mat, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China;

    Nanjing Med Univ, Affiliated Hosp 1, Dept Expt Radiat Oncol, Houston, TX 77030 USA;

    Nanjing Med Univ, Affiliated Hosp 1, Dept Expt Radiat Oncol, Houston, TX 77030 USA;

    Nankai Univ, Minist Educ, Key Lab Bioact Mat, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China;

    Nanjing Med Univ, Affiliated Hosp 1, Dept Expt Radiat Oncol, Houston, TX 77030 USA;

    Nanjing Med Univ, Affiliated Hosp 1, Dept Expt Radiat Oncol, Houston, TX 77030 USA;

    Nankai Univ, Minist Educ, Key Lab Bioact Mat, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    curcumin; radiation therapy; radiosensitization; self-assembling peptides; supramolecular nanofibers;

    机译：姜黄素;放射治疗;放射增敏;自组装肽;超分子纳米纤维;

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