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Functionally Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair

机译：功能分级的骨和肌腱状聚氨酯，用于肩袖修复

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Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylene diisocyante (H), and methacrylic anhydride (M; QHM polymers), which are free of solvent, catalyst, and photoinitiator, is developed. Mechanical characterization studies demonstrate that QHM polymers possesses phototunable bone- and tendon-like tensile and compressive properties (12-74 MPa tensile strength, 0.6-2.7 GPa tensile modulus, 58-121 MPa compressive strength, and 1.5-3.0 GPa compressive modulus), including the capability to withstand 10 000 cycles of physiological tensile loading and reduce stress concentrations via stiffness gradients. Biophysicochemical studies demonstrate that QHM polymers have clinically favorable attributes vital to rotator cuff repair stability, including slow degradation profiles (5-30% mass loss after 8 weeks) with little-to-no cytotoxicity in vitro, exceptional suture retention ex vivo (2.79-3.56-fold less suture migration relative to a clinically available graft), and competent tensile properties (similar ultimate load but higher normalized tensile stiffness relative to a clinically available graft) as well as good biocompatibility for augmenting rat supraspinatus tendon repair in vivo. This work demonstrates functionally graded, bone-tendon-like biomaterials for interfacial tissue engineering.
机译：工程学上用于肩袖修复的生物材料的关键考虑因素包括类似骨腱的机械性能，以支持生理负荷和生物物理化学属性，从而长期稳定修复部位。在这项研究中，开发了一种不含溶剂，催化剂和光引发剂的基于四醇（Q），六亚甲基二异氰酸酯（H）和甲基丙烯酸酐（M; QHM聚合物）的可紫外线交联的聚氨酯。机械特性研究表明，QHM聚合物具有光可调性的类骨和肌腱拉伸​​和压缩特性（12-74 MPa拉伸强度，0.6-2.7 GPa拉伸模量，58-121 MPa压缩强度和1.5-3.0 GPa压缩模量），包括能够承受10000次生理拉伸负荷并通过刚度梯度降低应力集中的能力。生化化学研究表明，QHM聚合物具有对肩袖修复稳定性至关重要的临床上有利的属性，包括缓慢的降解过程（8周后质量损失5-30％），体外毒性极低甚至没有细胞毒性，离体缝线保留出色（2.79-相对于临床上可获得的移植物，缝合线迁移少了3.56倍），并且具有良好的拉伸性能（相对于临床上可获得的移植物，具有相似的极限载荷，但归一化的拉伸刚度较高），并且具有良好的生物相容性，可增强体内大鼠棘上肌腱的修复。这项工作演示了用于界面组织工程的功能分级的，类似于肌腱的生物材料。

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