• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery
【24h】

Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery

机译：酶促纳米机器人增强抗癌药物的传递

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of enzyme catalysis to power micro- and nanomotors exploiting biocompatible fuels has opened new ventures for biomedical applications such as the active transport and delivery of specific drugs to the site of interest. Here, urease-powered nanomotors (nanobots) for doxorubicin (Dox) anticancer drug loading, release, and efficient delivery to cells are presented. These mesoporous silica-based core-shell nanobots are able to self-propel in ionic media, as confirmed by optical tracking and dynamic light scattering analysis. A four-fold increase in drug release is achieved by nanobots after 6 h compared to their passive counterparts. Furthermore, the use of Dox-loaded nanobots presents an enhanced anticancer efficiency toward HeLa cells, which arises from a synergistic effect of the enhanced drug release and the ammonia produced at high concentrations of urea substrate. A higher content of Dox inside HeLa cells is detected after 1, 4, 6, and 24 h incubation with active nanobots compared to passive Dox-loaded nanoparticles. The improvement in drug delivery efficiency achieved by enzyme-powered nanobots may hold potential toward their use in future biomedical applications such as the substrate-triggered release of drugs in target locations.
机译：酶催化为利用生物相容性燃料的微型和纳米电动机提供动力已为生物医学应用开辟了新的业务，例如将特定药物主动运输和输送到感兴趣的部位。在这里，提出了由尿素酶驱动的纳米马达（纳米机器人），用于阿霉素（Dox）抗癌药物的装载，释放和有效递送至细胞。这些中孔二氧化硅基核壳纳米机器人能够在离子介质中自我推进，这已通过光学跟踪和动态光散射分析得到了证实。与被动机器人相比，纳米机器人在6小时后释放的药物增加了4倍。此外，使用载有Dox的纳米机器人可提高对HeLa细胞的抗癌效率，这是由于药物释放增强和在高浓度尿素底物下产生的氨的协同作用所致。与装载有被动Dox的纳米颗粒相比，在使用主动纳米机器人孵育1、4、6和24小时后，检测到HeLa细胞内部Dox含量更高。通过酶驱动的纳米机器人实现的药物输送效率的提高，可能会使其在未来的生物医学应用（例如在目标位置触发底物触发的药物释放）中具有使用潜力。

著录项

  • 来源
    《Advanced Functional Materials》 |2018年第25期|1705086.1-1705086.10|共10页
  • 作者

    Hortelao Ana C.; Patino Tania; Perez-Jimenez Ariadna; Blanco Angel; Sanchez Samuel;

  • 作者单位

    Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain;

    Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain;

    Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain;

    Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain;

    Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    drug delivery; enzymatic catalysis; nanobots; nanomachines; nanomotors;

    机译：药物输送;酶催化;纳米机器人;纳米机器;纳米马达;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号