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首页> 外文期刊>Advanced Functional Materials >Graphene-Enhanced 3D Chemical Mapping of Biological Specimens at Near-Atomic Resolution
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Graphene-Enhanced 3D Chemical Mapping of Biological Specimens at Near-Atomic Resolution

机译：接近原子分辨率的生物样品的石墨烯增强3D化学映射

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摘要

The direct imaging of individual atoms within the cellular context holds great potential for understanding the fundamental physical and chemical processes in organisms. Here, a novel approach for imaging of electrically insulated biological cells by introducing a graphene encapsulation approach to disguise the low-conductivity barrier is reported. Upon successful coating using a water-membrane-based protocol, the electrical properties of the graphene enable voltage pulsing field evaporation for atom probe tomography (APT). Low conductive specimens prepared from both Au nanoparticles and antibiotic-resistant bacterial cells have been tested. For the first time, a significant graphene-enhanced APT mass resolving power is also observed confirming the improved compositional accuracy of the 3D data. The introduction of 2D materials encapsulation lays the foundation for a breakthrough direction in specimen preparation from nanomembrane and nanoscale biological architectures for subsequent 3D near-atomic characterization.%1801439.1-1801439.9
机译：在细胞环境中对单个原子进行直接成像，对于理解生物体的基本物理和化学过程具有巨大的潜力。在此，报道了一种通过引入石墨烯封装方法来掩盖低电导性势垒的电绝缘生物细胞成像的新方法。使用基于水膜的协议成功进行涂覆后，石墨烯的电性能可实现原子脉冲断层扫描（APT）的电压脉冲场蒸发。已经测试了由金纳米颗粒和抗抗生素细菌细胞制备的低导电样品。首次观察到显着的石墨烯增强的APT质量分辨能力，证实了3D数据的合成精度提高。引入2D材料封装技术为从纳米膜和纳米尺度生物结构进行后续3D近原子表征的标本制备突破性方向奠定了基础。％1801439.1-1801439.9

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  • 来源
    《Advanced Functional Materials》 |2018年第32期|1801439.1-1801439.9|共9页
  • 作者

    Adineh Vahid R.; Zheng Changxi; Zhang Qianhui; Marceau Ross K. W.; Liu Boyin; Chen Yu; Si Kae J.; Weyland Matthew; Velkov Tony; Cheng Wenlong; Li Jian; Fu Jing;

  • 作者单位

    Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia;

    Monash Univ, Dept Civil Engn, Clayton, Vic 3800, Australia;

    Monash Univ, Dept Civil Engn, Clayton, Vic 3800, Australia;

    Deakin Univ, Inst Frontier Mat, Geelong, Vic 3216, Australia;

    Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia;

    Monash Univ, Monash Ctr Electron Microscopy, Clayton, Vic 3800, Australia;

    Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia;

    Monash Univ, Monash Ctr Electron Microscopy, Clayton, Vic 3800, Australia;

    Univ Melbourne, Dept Pharmacol & Therapeut, Sch Biomed Sci, Fac Med Dent & Hlth Sci, Parkville, Vic 3010, Australia;

    Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia;

    Monash Univ, Dept Microbiol, Monash Biomed Discovery Inst, Clayton, Vic 3800, Australia;

    Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia;

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  • 正文语种 eng
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  • 关键词

    atom probe tomography; cellular imaging; graphene;

    机译：原子探针层析成像;细胞成像;石墨烯;

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