Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Li Xingshu; Kolemen Safacan; Yoon Juyoung; Akkaya Engin U.

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Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

机译：可活化的光敏剂：选择性光动力疗法的代理

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Recent developments in the design of bifunctional and activatable photo-sensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, the most promising results have come from studies aimed at gaining precise control over the location and rate of cytotoxic singlet oxygen generation. As a consequence, higher selectivities and efficiencies in photodynamic treatment protocols are now within reach. This feature article highlights the variety of approaches that have been pursued to improve photodynamic therapy and to transform simple photosensitizers into smarter theranostic agents.

机译：双功能和可活化光敏剂设计的最新进展使光动力敏化和光动力疗法的衰老领域焕发了青春。尽管系统研究发现了可用作潜在光敏剂的新型染料，但最有希望的结果来自旨在精确控制细胞毒性单线态氧生成的位置和速率的研究。结果，现在可以达到光动力治疗方案中更高的选择性和效率。这篇专题文章重点介绍了为改善光动力疗法并将简单的光敏剂转变为更聪明的治疗剂所采用的各种方法。

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《Advanced Functional Materials》 |2017年第5期|1604053.1-1604053.11|共11页
作者
Li Xingshu; Kolemen Safacan; Yoon Juyoung; Akkaya Engin U.;
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Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea;

Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey;

Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea;

Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey|Bilkent Univ, Dept Chem, TR-06800 Ankara, Turkey;

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1. ROS-Responsive Activatable Photosensitizing Agent for Imaging and Photodynamic Therapy of Activated Macrophages [J] . Hyunjin Kim, Youngmi Kim, In-Hoo Kim, Theranostics . 2014,第1期

机译：用于活化巨噬细胞成像和光动力治疗的ROS响应活化光敏剂
2. Quantum dot anti-CD conjugates: Are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? [J] . Bakalova R, Ohba H, Zhelev Z, Nano letters . 2004,第9期

机译：量子点抗CD偶联物：在癌症的光动力治疗中，它们是否是潜在的光敏剂或经典光敏剂的增效剂？
3. Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer [J] . da Silva Luis Pinto, Nunez-Montenegro Ara, Magalhaes Carla M., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：单分子化学发光光敏剂，用于癌症的自激酶和肿瘤选择性光动力学治疗
4. Metal-based phthalocyanines as a potential photosensitizing agent in photodynamic therapy for the treatment of melanoma skin cancer [C] . Kaminee Maduray, Bharti Odhav Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXIII . 2014

机译：金属基酞菁在光动力疗法中用于治疗黑素瘤皮肤癌的潜在光敏剂
5. Photodynamic therapy of urologic malignancies: Strategies for selective photosensitization. [D] . Xiao, Zhengwen. 1999

机译：泌尿系统恶性肿瘤的光动力疗法：选择性光敏化的策略。
6. ROS-Responsive Activatable Photosensitizing Agent for Imaging and Photodynamic Therapy of Activated Macrophages [O] . Hyunjin Kim, Youngmi Kim, In-Hoo Kim, 2014

机译：用于活化巨噬细胞成像和光动力治疗的ROS响应活化光敏剂
7. ROS-Responsive Activatable Photosensitizing Agent for Imaging and Photodynamic Therapy of Activated Macrophages [O] . Hyunjin Kim, Youngmi Kim, In-Hoo Kim, 2014

机译：用于成像和光动力学治疗活性巨噬细胞的ROS响应性活性光敏剂

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

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