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Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs

机译：金纳米复合生物墨水，用于打印3D心脏构造

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摘要

Bioprinting is the most convenient microfabrication method to create biomimetic three-dimensional (3D) cardiac tissue constructs, that can be used to regenerate damaged tissue and provide platforms for drug screening. However, existing bioinks, which are usually composed of polymeric biomaterials, are poorly conductive and delay efficient electrical coupling between adjacent cardiac cells. To solve this problem, a gold nanorod (GNR)-incorporated gelatin methacryloyl (GelMA)-based bioink is developed for printing 3D functional cardiac tissue constructs. The GNR concentration is adjusted to create a proper microenvironment for the spreading and organization of cardiac cells. At optimized concentrations of GNR, the nanocomposite bioink has a low viscosity, similar to pristine inks, which allows for the easy integration of cells at high densities. As a result, rapid deposition of cell-laden fibers at a high resolution is possible, while reducing shear stress on the encapsulated cells. In the printed GNR constructs, cardiac cells show improved cell adhesion and organization when compared to the constructs without GNRs. Furthermore, the incorporated GNRs bridge the electrically resistant pore walls of polymers, improve the cell-to-cell coupling, and promote synchronized contraction of the bioprinted constructs. Given its advantageous properties, this gold nanocomposite bioink may find wide application in cardiac tissue engineering.
机译：生物打印是创建仿生三维（3D）心脏仿生组织构造的最便捷的微细加工方法，可用于再生受损组织并提供药物筛选的平台。但是，现有的通常由聚合生物材料组成的生物墨水导电性差，并且延迟了相邻心脏细胞之间的有效电耦合。为解决此问题，开发了一种掺有金纳米棒（GNR）的明胶甲基丙烯酰基（GelMA）基生物墨水，用于打印3D功能性心脏组织构造。调节GNR的浓度以创造合适的微环境，使心脏细胞散布和组织。在优化的GNR浓度下，纳米复合生物墨水具有与原始墨水相似的低粘度，从而可以轻松地以高密度整合细胞。结果，可以以高分辨率快速沉积载有细胞的纤维，同时减少在包封的细胞上的剪切应力。与没有GNR的构建体相比，在印刷的GNR构建体中，心脏细胞显示出改善的细胞粘附和组织。此外，掺入的GNRs桥接聚合物的电阻性孔壁，改善细胞间的偶联，并促进生物打印构建体的同步收缩。鉴于其优越的性能，这种金纳米复合生物墨水可在心脏组织工程中找到广泛的应用。

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  • 来源
    《Advanced Functional Materials》 |2017年第12期|1605352.1-1605352.12|共12页
  • 作者

    Zhu Kai; Shin Su Ryon; van Kempen Tim; Li Yi-Chen; Ponraj Vidhya; Nasajpour Amir; Mandla Serena; Hu Ning; Liu Xiao; Leijten Jeroen; Lin Yi-Dong; Hussain Mohammad Asif; Zhang Yu Shrike; Tamayol Ali; Khademhosseini Ali;

  • 作者单位

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Fudan Univ, Zhongshan Hosp, Dept Cardiac Surg, Shanghai 200032, Peoples R China;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Univ Twente, Dept Dev BioEngn, NL-7522 NB Enschede, Overijssel, Netherlands;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Genet & Cardiovasc Med, Boston, MA 02115 USA;

    King Abdulaziz Univ, Dept Elect & Comp Engn, Jeddah 21569, Saudi Arabia;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Cambridge, MA 02139 USA|MIT, Harvard Mit Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA|Konkuk Univ, Coll Anim Biosci & Technol, Dept Bioind Technol, Seoul 143701, South Korea|King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia;

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