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首页> 外文期刊>Advanced Functional Materials >Anisotropy in Shape and Ligand-Conjugation of Hybrid Nanoparticulates Manipulates the Mode of Bio-Nano Interaction and Its Outcome
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Anisotropy in Shape and Ligand-Conjugation of Hybrid Nanoparticulates Manipulates the Mode of Bio-Nano Interaction and Its Outcome

机译：纳米粒子的形状和配体结合的各向异性操纵了生物-纳米相互作用的模式及其结果。

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摘要

In an attempt to manipulate the biological features of nanomaterials via both anisotropic shape and ligand modification, four types of nanoparticulates with good morphological stability are designed and engineered, including hybrid nanospheres, nanodiscs, and nanodiscs with edge modification or plane modification of octa-arginine (R8) sequence. It is found that the R8 modification anisotropy can trigger huge differences in the endocytosis, intracellular trafficking, and even tissue penetration of nanoparticulates. From plane modification to edge modification of R8, the maximum increase in cell uptake is up to 17-fold, which is much more significant than shape anisotropy alone. On the other hand, six types of different cell lines are investigated to simulate biological microenvironment. It is demonstrated that the maximum difference in cell uptake among six cell lines is 12-fold. Three main driving forces are found to contribute to such bio-nano interactions. Based on the findings of this study, it seems possible to manipulate the biointeraction mode of nanomaterials and its output by regulating their anisotropy in both shape and ligand modification.
机译：为了通过各向异性的形状和配体修饰来控制纳米材料的生物学特性，设计并设计了四种具有良好形态学稳定性的纳米颗粒，包括杂化纳米球，纳米圆片和经八边精氨酸边缘修饰或平面修饰的纳米圆片（ R8）序列。已经发现，R8修饰的各向异性可以触发内吞作用，细胞内运输以及甚至纳米颗粒的组织渗透方面的巨大差异。从平面修饰到R8的边缘修饰，细胞摄取的最大增加高达17倍，这比单独的形状各向异性要重要得多。另一方面，研究了六种类型的不同细胞系，以模拟生物微环境。已经证明，在六个细胞系中细胞摄取的最大差异是12倍。发现三个主要驱动力促成这种生物-纳米相互作用。根据这项研究的发现，似乎可以通过调节形状和配体修饰的各向异性来操纵纳米材料的生物相互作用模式及其输出。

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  • 来源
    《Advanced Functional Materials》 |2017年第31期|1700406.1-1700406.11|共11页
  • 作者

    Wang Xiaoyou; Lin Li; Liu Renfa; Chen Min; Chen Binlong; He Bo; He Bing; Liang Xiaolong; Dai Wenbing; Zhang Hua; Wang Xueqing; Wang Yiguang; Dai Zhifei; Zhang Qiang;

  • 作者单位

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

    Peking Univ, Sch Pharmaceut Sci, Coll Engn, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100871, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    delivery manipulation; endocytosis; ligand-modification anisotropy; nanodiscs; shape anisotropy;

    机译：传递操纵;胞吞作用;配体修饰各向异性;纳米;形状各向异性;

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