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首页> 外文期刊>Advanced Functional Materials >In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers
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In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers

机译：通过超灵敏的红外纳米温度计进行体内皮下热视频记录

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摘要

Some of the old and unrealizable dreams of biomedicine have become possible thanks to the appearance of novel advanced materials such as luminescent nanothermometers, nanoparticles capable of providing a contactless thermal reading through their light emission properties. Luminescent nanothermometers have already been demonstrated to be capable of in vivo subcutaneous punctual thermal reading but their real application as diagnosis tools still requires demonstrating their actual capacity for the acquisition of in vivo, time-resolved subcutaneous thermal images. The transfer from 1D to 2D subcutaneous thermal sensing is blocked in the last years mainly due to the lack of high sensitivity luminescent nanothermometers operating in the infrared biological windows. This work demonstrates how core/shell engineering, in combination with selective rare earth doping, can be used to develop supersensitive infrared luminescent nanothermometers. Erbium, thulium, and ytterbium core-shell LaF3 nanoparticles, operating within the biological windows, provide thermal sensitivities as large as 5% degrees C-1. This "record" sensitivity has allowed for the final acquisition of subcutaneous thermal videos of a living animal. Subsequent analysis of thermal videos allows for an unequivocal determination of intrinsic properties of subcutaneous tissues, opening the venue to the development of novel thermal imaging-based diagnosis tools.
机译：由于出现了新型先进材料，例如发光纳米温度计，能够通过其发光特性提供非接触式热读数的纳米材料，生物医学的一些古老而无法实现的梦想成为可能。发光纳米温度计已被证明能够在体内进行皮下点热读数，但其作为诊断工具的实际应用仍需要证明其在体内获取时间分辨的皮下热图像的实际能力。近年来，从1D到2D皮下热感测的转换受到阻碍，这主要是由于在红外生物窗口中缺少高灵敏度的发光纳米温度计的缘故。这项工作演示了如何将核/壳工程与选择性稀土掺杂相结合来开发超灵敏的红外发光纳米温度计。在生物窗口内运行的，th和核壳LaF3纳米颗粒可提供高达5％C-1的热敏性。这种“记录”的敏感性允许最终获取活体动物的皮下热影像。热视频的后续分析可以明确确定皮下组织的内在特性，从而为开发新型基于热成像的诊断工具打开了空间。

著录项

  • 来源
    《Advanced Functional Materials》 |2017年第38期|1702249.1-1702249.10|共10页
  • 作者

    Ximendes Erving C.; Rocha Ueslen; Sales Tasso O.; Fernandez Nuria; Sanz-Rodriguez Francisco; Martin Inocencio R.; Jacinto Carlos; Jaque Daniel;

  • 作者单位

    Univ Fed Alagoas, Grp Foton & Fluidos Complexos, Inst Fis, BR-57072900 Maceio, AL, Brazil|Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Fis Mat, Fac Ciencias, E-28049 Madrid, Spain;

    Univ Fed Alagoas, Grp Foton & Fluidos Complexos, Inst Fis, BR-57072900 Maceio, AL, Brazil;

    Univ Fed Alagoas, Grp Foton & Fluidos Complexos, Inst Fis, BR-57072900 Maceio, AL, Brazil;

    Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Fis Mat, Fac Ciencias, E-28049 Madrid, Spain|Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain;

    Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Fis Mat, Fac Ciencias, E-28049 Madrid, Spain|Hosp Ramon & Cajal, IRYCIS, E-28034 Madrid, Spain|Univ Autonoma Madrid, Dept Biol, E-28049 Madrid, Spain;

    Univ La Laguna, Dept Fis, IMN, Av Astrofis Francisco Sanchez S-N, E-38206 San Cristobal la Laguna, Tenerife, Spain;

    Univ Fed Alagoas, Grp Foton & Fluidos Complexos, Inst Fis, BR-57072900 Maceio, AL, Brazil;

    Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Fis Mat, Fac Ciencias, E-28049 Madrid, Spain|Hosp Ramon & Cajal, IRYCIS, E-28034 Madrid, Spain;

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  • 正文语种 eng
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  • 关键词

    biological windows; nanoparticles; subcutaneous thermal imaging; thermal sensing;

    机译：生物窗;纳米粒子;皮下热成像;热感测;

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