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首页> 外文期刊>Advanced Functional Materials >Development of a Dual-Modally Traceable Nanoplatform for Cancer Theranostics Using Natural Circulating Cell-Derived Microparticles in Oral Cancer Patients
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Development of a Dual-Modally Traceable Nanoplatform for Cancer Theranostics Using Natural Circulating Cell-Derived Microparticles in Oral Cancer Patients

机译：使用天然循环细胞衍生微粒在口腔癌患者中开发双模态可追踪纳米平台用于癌症治疗学。

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摘要

Cell-derived microparticles (MPs), which are biogenic nanosized membrane vesicles that convey bioactive molecules between cells, have exhibited great potential to serve as therapeutic platforms. However, so far, all the MPs used as theranostic vectors in previous studies have been produced in vitro from cell culture supernatants, which is still associated with several concerns regarding practical applications. In this study, circulating MPs (CMPs), which are freshly purified from the peripheral blood of oral squamous cell carcinoma (OSCC) patients, are directly and efficiently embedded with ultrasmall near-infrared-fluorescent magnetic quantum dots (Ag2Se@Mn QDs) via electroporation. By virtue of the superior photostability, favorable biocompatibility, and dual-mode traceability of Ag2Se@Mn QD-labeled CMPs in vivo, the tissue distribution and natural tumor-targeting behavior of CMPs from OSCC patients are directly visualized in living mice for the first time. Moreover, by simultaneously embedding antitumor siRNA and Ag2Se@Mn QDs into CMPs derived from OSCC patients, a dual-modally traceable and actively tumor-targeted nanoplatform for cancer theranostics is developed. This study reports the first reliable conjugation-free labeling strategy for in vivo dual-mode tracking of CMPs harvested from the human body, and, more importantly, reports the development of traceable tumor-targeted theranostic vectors based on naturally occurring CMPs from cancer patients.
机译：细胞来源的微粒（MPs）是在细胞之间传递生物活性分子的生物纳米级膜囊泡，具有巨大的潜力可作为治疗平台。但是，到目前为止，先前研究中用作治疗诊断载体的所有MP都是从细胞培养上清液中体外产生的，这仍然与实际应用中的一些问题相关。在这项研究中，从口腔鳞状细胞癌（OSCC）患者外周血中新鲜纯化的循环MP（CMP）通过以下途径直接有效地嵌入超小型近红外荧光磁量子点（Ag2Se @ Mn QDs）：电穿孔。由于Ag2Se @ Mn QD标记的CMP在体内具有优异的光稳定性，良好的生物相容性和双模式可追溯性，因此首次在活体小鼠中直接观察到了来自OSCC患者的CMP的组织分布和天然肿瘤靶向行为。此外，通过同时将抗肿瘤siRNA和Ag2Se @ Mn QD嵌入源自OSCC患者的CMP中，开发了用于癌症治疗的双模态可追踪且主动靶向肿瘤的纳米平台。这项研究报告了从体内收获的CMP的体内双模式追踪的第一种可靠的无偶联标记策略，更重要的是，报告了基于癌症患者天然存在的CMP的可追踪的靶向肿瘤的治疗方法的开发。

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  • 来源
    《Advanced Functional Materials》 |2017年第40期|1703482.1-1703482.15|共15页
  • 作者

    Yu Zi-Li; Zhang Wei; Zhao Jing-Ya; Zhong Wen-Qun; Ren Jian-Gang; Wu Min; Zhang Zhi-Ling; Pang Dai-Wen; Zhao Yi-Fang; Chen Gang;

  • 作者单位

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

    Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

    Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

    Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China|Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 237 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    dual-mode tracking; microparticles; nanovectors; oral cancer; quantum dots;

    机译：双模跟踪微粒纳米载体口腔癌量子点;

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