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首页> 外文期刊>Biomaterials Science >Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics
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Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

机译：生态友好友好发展的二模影像引导癌症治疗癌症的超释放纳米纳薄机

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摘要

Success in disease therapy depends on precision medicines, where development of formulations with diagnostic and therapeutic functions is quite important. In this study, multifunctional theranostics based on a magnetic graphene oxide (GO) nanohybrid (GIPD) has been developed for magnetic resonance (MR) imaging-guided chemo-photothermal therapy of cancer. The GIPD is endowed with T-1/T-2 MR imaging capacity via precipitation of small-sized IONP nanoparticles (8.25 +/- 2.25 nm) on GO nanosheets through a mild friendly way (60 degrees C for 1 h, no organic solvent). The obtained nanocomposite is then non-covalently decorated with phosphine oxide polyethylene glycol to improve biosafety. The final nanohybrid effectively loads doxorubicin as the model chemotherapeutic drug and is found to have in vivo T-1/T-2 MR bimodal imaging functions. Both the in vitro and in vivo results demonstrate that the GO-based nanoplatform displays a good remote photothermal effect, which can damage the dense shell of solid tumor tissue, thereby facilitating the delivery of anticancer drugs into tumor cells. Therefore, this theranostic nanoplatform enables a potent combined chemo-photothermal anticancer efficacy, holding great potential for exploitation of precision cancer therapy.
机译：疾病治疗的成功取决于精密药物，其中具有诊断和治疗功能的配方的开发非常重要。在该研究中，已经开发了基于磁性石墨烯氧化物（GO）纳米氧化物（GIPD）的多功能治疗方法用于癌症的磁共振（MR）成像引导的癌症。通过轻度友好的方式，GIPD通过小尺寸的IONP纳米颗粒（8.25 +/- 2.25nm）析出小尺寸的IONP纳米颗粒（8.25 +/- 2.25nm）赋予T-1 / T-2 MR成像能力（60摄氏度1小时，没有有机溶剂）。然后将所得纳米复合材料与氧化膦聚乙烯二醇非共价装饰，以改善生物安全性。最终的纳米冬次冬次冬次冬次含量有效地称为模型化学治疗药物的多柔比蛋白，并发现体内T-1 / T-2 MR双峰成像功能。体外和体内结果都表明，去的纳米纳薄形式显示出良好的远程光热效应，这可能会损伤固体肿瘤组织的致密壳，从而促进抗癌药物递送到肿瘤细胞中。因此，这种治疗纳米纳米型纳米纳薄机能够实现有效的组合的化学光热抗癌效果，占据精密癌症治疗的剥削潜力。

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  • 来源
    《Biomaterials Science》 |2020年第22期|共12页
  • 作者

    Li Yulin; Zheng Ling; Xiao Lan; Wang Liudi; Cui Jingyuan; Sha Dongyong; Liu Changsheng;

  • 作者单位

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

    Queensland Univ Technol Inst Hlth &

    Biomed Innovat 60 Musk Ave Brisbane Qld 4059 Australia;

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Minist Educ Engn Res Ctr Biomed Mat State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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