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首页> 外文期刊>Advanced Functional Materials >An O-2 Self-Supplementing and Reactive-Oxygen-Species-Circulating Amplified Nanoplatform via H2O/H2O2 Splitting for Tumor Imaging and Photodynamic Therapy
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An O-2 Self-Supplementing and Reactive-Oxygen-Species-Circulating Amplified Nanoplatform via H2O/H2O2 Splitting for Tumor Imaging and Photodynamic Therapy

机译：通过H2O / H2O2分裂的O-2自补充和活性氧物种循环的放大的纳米平台用于肿瘤成像和光动力疗法。

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摘要

Conventional photodynamic therapy (PDT) has limited applications in clinical cancer therapy due to the insufficient O-2 supply, inefficient reactive oxygen species (ROS) generation, and low penetration depth of light. In this work, a multifunctional nanoplatform, upconversion nanoparticles (UCNPs)@TiO2@MnO2 core/shell/sheet nanocomposites (UTMs), is designed and constructed to overcome these drawbacks by generating O-2 in situ, amplifying the content of singlet oxygen (O-1(2)) and hydroxyl radical (center dot OH) via water-splitting, and utilizing 980 nm near-infrared (NIR) light to increase penetration depth. Once UTMs are accumulated at tumor site, intracellular H2O2 is catalyzed by MnO2 nanosheets to generate O-2 for improving oxygen-dependent PDT. Simultaneously, with the decomposition of MnO2 nanosheets and 980 nm NIR irradiation, UCNPs can efficiently convert NIR to ultraviolet light to activate TiO2 and generate toxic ROS for deep tumor therapy. In addition, UCNPs and decomposed Mn2+ can be used for further upconversion luminescence and magnetic resonance imaging in tumor site. Both in vitro and in vivo experiments demonstrate that this nanoplatform can significantly improve PDT efficiency with tumor imaging capability, which will find great potential in the fight against tumor.
机译：常规的光动力疗法（PDT）由于O-2供应不足，活性氧（ROS）生成效率低以及光的穿透深度低，在临床癌症治疗中的应用受到限制。在这项工作中，设计并构建了一种多功能纳米平台，上转换纳米颗粒（UCNPs）@ TiO2 @ MnO2核/壳/片状纳米复合材料（UTM），以通过就地生成O-2，放大单重态氧的含量来克服这些缺点（ O-1（2））和羟基自由基（中心点OH）通过水分解，并利用980 nm近红外（NIR）光增加穿透深度。一旦UTM累积在肿瘤部位，MnO2纳米片就会催化细胞内H2O2生成O-2，以改善氧依赖性PDT。同时，随着MnO2纳米片的分解和980 nm NIR辐射的分解，UCNP可以有效地将NIR转换为紫外光以激活TiO2并产生有毒的ROS，用于深部肿瘤治疗。此外，UCNPs和分解的Mn2 +可用于进一步上转换发光和肿瘤部位的磁共振成像。体外和体内实验均表明，该纳米平台可以显着提高PDT的效率和肿瘤成像能力，这将在对抗肿瘤方面具有巨大潜力。

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  • 来源
    《Advanced Functional Materials》 |2017年第43期|1700626.1-1700626.14|共14页
  • 作者

    Zhang Chi; Chen Wei-Hai; Liu Li-Han; Qiu Wen-Xiu; Yu Wu-Yang; Zhang Xian-Zheng;

  • 作者单位

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Hubei, Peoples R China|Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    hypoxic tumors; photodynamic therapy; reactive oxygen species; upconversion nanoparticles; water-splitting;

    机译：低氧性肿瘤;光动力疗法;活性氧;上转换纳米粒子;水分解;

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