• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy
【24h】

Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy

机译：顺铂前体药物构建的脂质体，作为用于双峰成像的多功能治疗性纳米纳米平台指导联合癌症治疗。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Up to date, a large variety of liposomal nanodrugs have been explored for cancer nanomedicine, showing encouraging results in both preclinical animal experiments and clinical treatment of cancer patients. Herein, a phospholipid conjugated with a cisplatin prodrug is used as the major structure component of liposomes together with other commercial lipids via self-assembling. By doping with 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR), a lipophilic dye with strong near infrared (NIR) absorbance and fluorescence, the obtained DiR-Pt(IV)-liposome is found to be an effective probe for in vivo NIR fluorescence and photoacoustic bimodal imaging. Attributing to its intrinsically doped cis-Pt(IV) prodrug, efficient photothermal conversion ability, and excellent tumor homing ability, DiR-Pt(IV)-liposome confers greatly enhanced therapeutic outcomes in the combined photothermal-chemotherapy. Moreover, Pt(IV)-liposome is also demonstrated to be an efficient carrier for both small hydrophilic molecules and proteins, which are encapsulated inside the water-cavity of liposomes, further demonstrating the versatile functions of this nanoplatform. This study develops a unique type of liposomal nanomedicine with a prodrug conjugated phospholipid as the major structure component. Such Pt(IV)-liposome is featured with advantages including precisely defined/easily tunable drug compositions, stealth-like pharmacokinetics, efficient tumor passive uptake, and the capabilities to simultaneously load with various types of imaging or therapeutic agents.
机译：迄今为止，已开发出多种脂质体纳米药物用于癌症纳米药物，在临床前动物实验和癌症患者的临床治疗中均显示出令人鼓舞的结果。本文中，与顺铂前药缀合的磷脂通过自组装与其他市售脂质一起用作脂质体的主要结构组分。通过掺入具有强近红外（NIR）吸光度和荧光的亲脂性染料1,1-二十八烷基-3,3,3,3-四甲基吲哚并花青碘化物（DiR），发现获得的DiR-Pt（IV）-脂质体是体内NIR荧光和光声双峰成像的有效探针。 DiR-Pt（IV）-脂质体归因于其固有地掺杂的顺式-Pt（IV）前药，有效的光热转化能力和出色的肿瘤归巢能力，在联合光热化学疗法中可大大提高治疗效果。此外，Pt（IV）-脂质体还被证明是封装在脂质体的水腔内的亲水性小分子和蛋白质的有效载体，进一步证明了该纳米平台的多功能性。这项研究开发了一种独特的脂质体纳米药物，其前药结合的磷脂为主要结构成分。这种Pt（IV）-脂质体的特征在于具有以下优点：精确定义/易于调节的药物组合物，隐身样药代动力学，有效的肿瘤被动摄取以及同时加载各种类型的成像或治疗剂的能力。

著录项

  • 来源
    《Advanced Functional Materials》 |2016年第13期|2207-2217|共11页
  • 作者

    Feng Liangzhu; Gao Min; Tao Danlei; Chen Qian; Wang Hairong; Dong Ziliang; Chen Meiwan; Liu Zhuang;

  • 作者单位

    Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China|Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

    Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cisplatin prodrug; combined chemo- and photothermal therapy; liposomal photothermal agent; NIR fluorescence and PA bimodal imaging;

    机译：顺铂前药;化学和光热疗法联合;脂质体光热剂;NIR荧光和PA双峰成像;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号