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首页> 外文期刊>Advanced Functional Materials >Dual-Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy
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Dual-Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy

机译：纳米胶束对多种胶束/疏水药物的双重靶向光穿透递送，以增强肿瘤治疗

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摘要

A photoresponsive pea-like capsule (nanopea) that also represents a photothermal agent is constructed by wrapping multiple polymer micelles (polyvinyl alcohol, PVA) in reduced graphene oxide nanoshells through a double emulsion approach. Resulting nanopeas can transport multiple PVA micelles containing the fully concealed hydrophobic drug docetaxel (DTX) which can be later released by a near-infrared photoactuation trigger. Through integrating the rod-shaped adhesion and lactoferrin (Lf) targeting, the nanopea enhances both uptake by cancer cellc in vitro and particle accumulation at tumor in vivo. A photopenetrative delivery of micelles/DTX to the tumor site is actuated by NIR irradiation which ruptures the nanopeas as well as releases nanosized micelles/DTX. This trigger also results in thermal damage to the tumor and increases the micelles/DTX permeability, facilitating drug penetration into the deep tumor far from blood vessels for thermal chemotherapy. This nanopea with the capability of imaging, enhanced tumor accumulation, NIR-triggered tumor penetration, and hyperthermia ablation for photothermal chemotherapy boosts tumor treatment and shows potential for use in other biological applications.
机译：通过双乳液方法将多个聚合物胶束（聚乙烯醇，PVA）包裹在还原的氧化石墨烯纳米壳中，构建了一种也代表光热剂的光响应性豌豆状胶囊（纳米豆）。所得的纳米豌豆可以转运多个含有完全隐藏的疏水性药物紫杉萜（DTX）的PVA胶束，随后可通过近红外光致动触发器将其释放。通过整合棒状粘附力和乳铁蛋白（Lf）靶向，纳米豌豆既增强了癌细胞的体外摄取，又增强了体内肿瘤的颗粒蓄积。胶束/ DTX向肿瘤部位的光穿透传递是通过NIR辐射激活的，它会破坏纳米豌豆并释放纳米尺寸的胶束/ DTX。该触发物还导致对肿瘤的热损伤，并增加了胶束/ DTX的渗透性，从而促进了药物从远离血管的深部肿瘤渗透到热化疗中。这种纳米豆具有成像能力，增强的肿瘤蓄积能力，NIR触发的肿瘤渗透能力以及用于光热化学疗法的高温消融技术，可以促进肿瘤治疗，并显示出在其他生物学应用中的潜力。

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  • 来源
    《Advanced Functional Materials》 |2016年第23期|4169-4179|共11页
  • 作者

    Lin Chien-Ting; Lin I-Chieh; Sung Shou-Yuan; Su Yu-Lin; Huang Yu-Fen; Chiang Chi-Shiun; Hu Shang-Hsiu;

  • 作者单位

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

    Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan;

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