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Reality Check for Nanomaterial-Mediated Therapy with 3D Biomimetic Culture Systems

机译：纳米材料介导的3D仿生培养系统疗法的真实性检查

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摘要

The recent progresses in tissue engineering and nanomaterial-based therapeutics/theranostics have led to the ever increasing utilization of 3D in vitro experimental models as the bona fide culture systems to evaluate the therapeutic/theranostic effects of nanomedicine. Compared to the use of conventional 2D culture platforms, 3D biomimetic cultures offer unmatched advantages as relevant physiological and pathological elements can be incorporated to allow better characterization of the engineered bio-nanomaterials in the targeted tissue-specific microenvironment. In this Feature Article, the current state-of-the-art 3D in vitro models that have been developed for the evaluation of biosafety and efficacy of nano-therapeutics/theranostics targeting the colon, blood-brain barrier (BBB), lungs, skin tumor models to bridge the nanomedicine bench to pre-clinical ravine are reviewed. Furthermore, the critical physicochemical parameters of the bio-nanomaterials that govern its transport and biodistribution in a complex 3D microenvironment will be highlighted. The major challenges and future prospects of evaluating nanomedicine in the third dimension will also be discussed.
机译：组织工程和基于纳米材料的治疗/热疗学的最新进展已导致3D体外实验模型作为真正的培养系统来评估纳米药物的治疗/热疗效果的利用率不断提高。与使用常规2D培养平台相比，3D仿生培养提供了无与伦比的优势，因为可以结合相关的生理和病理成分，以在目标组织特定的微环境中更好地表征工程化的生物纳米材料。在本专题文章中，已开发了当前最新的3D体外模型，用于评估针对结肠，血脑屏障（BBB），肺，皮肤的纳米疗法/热疗法的生物安全性和有效性审查了将纳米医学平台与临床前沟壑联系起来的肿瘤模型。此外，将重点介绍生物纳米材料在复杂的3D微环境中控制其运输和生物分布的关键物理化学参数。还将讨论在三维中评估纳米药物的主要挑战和未来前景。

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  • 来源
    《Advanced Functional Materials》 |2016年第23期|4046-4065|共20页
  • 作者

    Tay Chor Yong; Muthu Madaswamy S.; Chia Sing Ling; Kim Truc Nguyen; Feng Si-Shen; Leong David Tai;

  • 作者单位

    Nanyang Technol Univ, Sch Mat Sci & Engn, N4-1,Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore;

    Indian Inst Technol BHU, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India;

    Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, N4-1,Nanyang Ave, Singapore 639798, Singapore;

    Second Mil Med Univ, Int Joint Canc Inst, 800 Xiang Yin Rd, Shanghai 200433, Peoples R China;

    Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore;

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