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首页> 外文期刊>Advanced Functional Materials >Magnetic Mesoporous Nanocarriers for Drug Delivery with Improved Therapeutic Efficacy
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Magnetic Mesoporous Nanocarriers for Drug Delivery with Improved Therapeutic Efficacy

机译：磁性介孔纳米载体用于改善治疗效果的药物递送

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Mesoporous CoNi @ Au core @ shell nanorods are synthesized as magnetic drug nanocarriers by electrodeposition using ionic liquid-in-aqueous microemulsions. Mesoporous nanorods present a highly effective area (186 m(2) g(-1)) and magnetic character that allows their manipulation, concentration, and retention by applying a magnetic field. The nanorods have been functionalized with thiol-poly(ethyleneglycol) molecules, and molecules of Irinotecan, a drug used in chemotherapy, are retained in both the lattice of the linked thiol-poly(ethyleneglycol) molecules and inside the interconnected nanorods pores. The nanorods' mesoporous character allows a high drug. loading capability and magnetic behavior that allows the drug's controlled release. A high cellular viability of HeLa cells is obtained after their incubation with the nanorods functionalized with thiol-poly(ethyleneglycol). However, when the nanorods function as carriers for Irinotecan, significant cell death is occurred when HeLa cells are incubated with the functionalized, drug-loaded nanorods. Cell death is also produced by applying an alternating magnetic field due to both the effect of the release of Irinotecan from the carrier as to mechanical damage of cells by nanorods subjected to the effect of a magnetic field. The proposal to used mesoporous magnetic nanorods as drug carriers can thus dramatically reduce the amounts of both nanocarrier and drug needed to efficiently destroy cancer cells.
机译：介孔CoNi @ Au核@壳纳米棒是通过使用离子型水包液体微乳液电沉积而合成的，作为磁性药物纳米载体。介孔纳米棒具有很高的有效面积（186 m（2）g（-1））和磁性，可以通过施加磁场来进行操纵，浓缩和保留。纳米棒已经用硫醇-聚（乙二醇）分子功能化，用于化疗的药物伊立替康的分子既保留在连接的硫醇-聚（乙二醇）分子的晶格中，又保留在互连的纳米棒孔内。纳米棒的介孔特性使它具有很高的药效。允许药物控制释放的负载能力和磁性。将HeLa细胞与被硫醇-聚（乙二醇）功能化的纳米棒孵育后，可获得高细胞活力。但是，当纳米棒充当伊立替康的载体时，将HeLa细胞与功能化的，载有药物的纳米棒孵育时，会发生明显的细胞死亡。由于施加伊立替康从载体释放的两种作用以及受到磁场作用的纳米棒对细胞的机械损伤，通过施加交变磁场也会产生细胞死亡。因此，使用介孔磁性纳米棒作为药物载体的提议可以大大减少有效破坏癌细胞所需的纳米载体和药物的数量。

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  • 来源
    《Advanced Functional Materials》 |2016年第36期|6601-6611|共11页
  • 作者

    Serra Albert; Gimeno Nuria; Gomez Elvira; Mora Margarita; Lluisa Sagrista Maria; Valles Elisa;

  • 作者单位

    Univ Barcelona, Grp Electrodeposicio Capes Primes & Nanoestruct G, Dept Ciencia Mat & Quim Fis, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain|Univ Barcelona, Inst Nanociencia & Nanotecnol IN2UB, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain;

    Univ Barcelona, Grp Electrodeposicio Capes Primes & Nanoestruct G, Dept Ciencia Mat & Quim Fis, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain|Univ Barcelona, Inst Nanociencia & Nanotecnol IN2UB, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain;

    Univ Barcelona, Grp Electrodeposicio Capes Primes & Nanoestruct G, Dept Ciencia Mat & Quim Fis, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain|Univ Barcelona, Inst Nanociencia & Nanotecnol IN2UB, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain;

    Univ Barcelona, Fac Biol, Dept Bioquim & Biomed Mol, Grp Aplicac Biomed Sistemes Colloidals, Avinguda Diagonal 643, E-08028 Barcelona, Catalonia, Spain;

    Univ Barcelona, Fac Biol, Dept Bioquim & Biomed Mol, Grp Aplicac Biomed Sistemes Colloidals, Avinguda Diagonal 643, E-08028 Barcelona, Catalonia, Spain;

    Univ Barcelona, Grp Electrodeposicio Capes Primes & Nanoestruct G, Dept Ciencia Mat & Quim Fis, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain|Univ Barcelona, Inst Nanociencia & Nanotecnol IN2UB, Marti & Franques 1, E-08028 Barcelona, Catalonia, Spain;

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