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首页> 外文期刊>Advanced Functional Materials >A Versatile Nanotheranostic Agent for Efficient Dual-Mode Imaging Guided Synergistic Chemo-Thermal Tumor Therapy
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A Versatile Nanotheranostic Agent for Efficient Dual-Mode Imaging Guided Synergistic Chemo-Thermal Tumor Therapy

机译：用于高效双模成像的协同化学热疗肿瘤治疗的多功能Nanotheranostic剂。

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摘要

The integration of efficient imaging for diagnosis and synergistic tumor therapy into a single-component nanoplatform is much promising for high efficacy tumor treatment but still in a great challenge. Herein, a smart and versatile nanotheranostic platform based on hollow mesoporous Prussian blue nanoparticles (HMPBs) with perfluoropentane (PFP) and doxorubicin (DOX) inside, has been designed, for the first time, to achieve the distinct in vivo synergistic chemo-thermal tumor therapy and synchronous diagnosis and monitoring by ultrasound (US)/photoacoustic (PA) dual mode imaging. The prepared HMPBs show excellent photothermal conversion properties with large molar extinction coefficient (approximate to 1.2 x 10(11) M-1 cm(-1)) and extremely high photothermal conversion efficiency (41.4%). Such a novel theranostic nanoplatform is expected to overcome the inevitable tumor recurrence and metastasis resulting from the inhomogeneous ablation of single thermal therapy, which will find a promising prospect in the application of noninvasive cancer therapy.
机译：将用于诊断和协同肿瘤治疗的有效成像集成到单组分纳米平台中对于高效率肿瘤治疗非常有前途，但仍然面临巨大挑战。本文中，首次设计了基于空心介孔普鲁士蓝纳米颗粒（HMPBs）和内部全氟戊烷（PFP）和阿霉素（DOX）的智能多功能纳米治疗平台，以实现独特的体内协同化学热肿瘤。通过超声（US）/光声（PA）双模成像进行治疗和同步诊断与监测。制备的HMPBs具有出色的光热转换性能，具有大的摩尔消光系数（约1.2 x 10（11）M-1 cm（-1））和极高的光热转换效率（41.4％）。预期这种新颖的治疗疗法纳米平台将克服由单一热疗法的不均匀消融引起的不可避免的肿瘤复发和转移，这将在无创癌症疗法的应用中找到有希望的前景。

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  • 来源
    《Advanced Functional Materials》 |2015年第17期|2520-2529|共10页
  • 作者

    Cai Xiaojun; Jia Xiaoqing; Gao Wei; Zhang Kun; Ma Ming; Wang Shige; Zheng Yuanyi; Shi Jianlin; Chen Hangrong;

  • 作者单位

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400016, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400016, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

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