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首页> 外文期刊>Advanced Functional Materials >pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer
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pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

机译：pH和近红外光响应胶束与高热触发肿瘤穿透和细胞质药物释放逆转对阿霉素的耐药性。

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摘要

The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy of tumors. Herein, a novel hybrid micelle with pH and near-infrared (NIR) light dual-responsive property is reported for reversing doxorubicin (DOX) resistance in breast cancer. The hybrid micelles are designed to integrate the pH-and NIR light-responsive property of an amphiphilic diblock polymer and the high DOX loading capacity of a polymeric prodrug into one single nanocomposite. At physiological condition (i.e., pH 7.4), the micelles form compact nanostructure with particle size around 30 nm to facilitate blood circulation and passive tumor targeting. Meanwhile, the micelles are quickly dissociated in weakly acidic environment (i.e., pH <= 6.2) to release DOX prodrug. When exposed to NIR laser irradiation, the hybrid micelles can trigger notable tumor penetration and cytosol release of DOX payload by inducing tunable hyperthermia effect. In combination with localized NIR laser irradiation, the hybrid micelles significantly inhibit the growth of DOX-resistant MCF-7/ADR breast cancer in an orthotopic tumor bearing mouse model. Taken together, this pH and NIR light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release can be an effective nanoplatform to combat cancer MDR.
机译：获得多药耐药性（MDR）是成功进行肿瘤化疗的主要障碍。本文中，据报道具有pH和近红外（NIR）光双重响应特性的新型杂交胶束可逆转乳腺癌中对阿霉素（DOX）的抗性。杂化胶束旨在将两亲性二嵌段聚合物的pH和NIR光响应特性与聚合前药的高DOX负载能力整合到一个单一的纳米复合材料中。在生理条件（即pH 7.4）下，胶束形成紧凑的纳米结构，其粒径约为30 nm，以促进血液循环和被动靶向肿瘤。同时，胶束在弱酸性环境（即pH <= 6.2）中迅速解离以释放出DOX前药。当暴露于近红外激光照射下时，杂化胶束可通过诱导可调节的高热效应来触发明显的肿瘤渗透和DOX有效负载的胞质溶胶释放。结合局部NIR激光照射，杂种胶束在带有原位肿瘤的小鼠模型中显着抑制耐DOX的MCF-7 / ADR乳腺癌的生长。两者合计，具有热触发的肿瘤渗透和细胞质药物释放的pH和NIR光响应胶束可以是对抗癌症MDR的有效纳米平台。

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  • 来源
    《Advanced Functional Materials》 |2015年第17期|2489-2500|共12页
  • 作者

    Yu Haijun; Cui Zhirui; Yu Pengcheng; Guo Chengyue; Feng Bing; Jiang Tongying; Wang Siling; Yin Qi; Zhong Dafang; Yang Xiangliang; Zhang Zhiwen; Li Yaping;

  • 作者单位

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;

    Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab, Shanghai 201203, Peoples R China;

    Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

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