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首页> 外文期刊>Advanced Functional Materials >Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfide Nanoparticles
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Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfide Nanoparticles

机译：成像引导的联合光热和放射疗法使用碘131掺杂的硫化铜纳米粒子治疗皮下和转移性肿瘤。

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摘要

Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. Herein, by adding I-131 when making iodine-doped CuS nanoparticles, CuS/[I-131]I nanoparticles are obtained, which after functionalization with polyethylene glycol (PEG) are used for radiotherapy (RT) and photothermal therapy (PTT), by utilizing their intrinsic high near-infrared absorbance and the doped I-131-radioactivity, respectively. The combined RT and PTT based on CuS/[I-131]I-PEG is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. In the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (CT) imaging, it is found that CuS/[I-131]I-PEG nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. Importantly, the combined RT and PTT applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. In vivo toxicology studies further reveal that our CuS/I-PEG is not obviously toxic to animals at fourfold of the treatment dose. This work thus demonstrates the potential of combining RT and PTT using a single nanoagent for imaging-guided treatment of metastatic tumors.
机译：通过克服常规癌症疗法的局限性，结合不同的治疗策略来治疗癌症在基础研究和临床研究中都显示出了巨大的希望。在此，通过在制造碘掺杂的CuS纳米颗粒时添加I-131，获得CuS / [I-131] I纳米颗粒，其在用聚乙二醇（PEG）功能化后用于放射疗法（RT）和光热疗法（PTT），分别利用它们固有的高近红外吸收率和掺杂的I-131放射性。然后进行基于CuS / [I-131] I-PEG的RT和PTT结合治疗，达到了显着的协同治疗效果，如皮下肿瘤治疗所示。同时，如通过双峰核成像和计算机断层扫描（CT）成像所揭示的，发现将CuS / [I-131] I-PEG纳米颗粒注射入原发性实体瘤后可迁移并保留在其附近的前哨淋巴中节点。重要的是，在那些淋巴结上联合应用RT和PTT辅助原发肿瘤的手术切除，可显着抑制癌症转移并大大延长动物的生存期。体内毒理学研究进一步表明，我们的CuS / I-PEG在治疗剂量的四倍时对动物没有明显毒性。因此，这项工作证明了使用单一纳米剂将RT和PTT结合用于影像学指导的转移性肿瘤治疗的潜力。

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  • 来源
    《Advanced Functional Materials》 |2015年第29期|4689-4699|共11页
  • 作者

    Yi Xuan; Yang Kai; Liang Chao; Zhong Xiaoyan; Ning Ping; Song Guosheng; Wang Dongliang; Ge Cuicui; Chen Chunying; Chai Zhifang; Liu Zhuang;

  • 作者单位

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China;

    Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cancer metastasis; copper sulfide; multimodal imaging; photothermal therapy; radiotherapy;

    机译：癌转移;硫化铜;多模式成像;光热疗法;放射疗法;

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