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首页> 外文期刊>Advanced Functional Materials >Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbit[6]uril Derivatives
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Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbit[6]uril Derivatives

机译：基于具有葫芦[6] uril衍生物功能的有机晶体管的高灵敏度和选择性生物传感器

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摘要

Biosensors based on a field-effect transistor platform allow continuous monitoring of biologically active species with high sensitivity due to the amplification capability of detected signals. To date, a large number of sensors for biogenic substances have used high-cost enzyme immobilization methods. Here, highly sensitive organic field-effect transistor (OFET)-based sensors functionalized with synthetic receptors are reported that can selectively detect acetylcholine (ACh(+)), a critical ion related to the delivery of neural stimulation. A cucurbit[6]uril (CB[6]) derivative, perallyloxyCB[6] ((allyloxy)(12)CB[6], AOCB[6]), which is soluble in methanol but insoluble in water, has been solution-deposited as a selective sensing layer onto a water-stable p-channel semiconductor, 5,5-bis-(7-dodecyl-9H-fluoren-2-yl)-2,2-bithiophene layer. The OFET-based sensors exhibit a detection limit down to 1 x 10(-12) m of ACh(+), which is six orders of magnitude lower than that of ion-selective electrode-based sensors. Moreover, these OFET-based sensors show highly selective discrimination of ACh(+) over choline (Ch(+)). The findings demonstrate a viable method for the fabrication of OFET-based biosensors with high sensitivity and selectivity, and allow for practical applications of OFETs as high-performance sensors for biogenic substances.
机译：由于检测信号的放大能力，基于场效应晶体管平台的生物传感器可以高灵敏度连续监测生物活性物质。迄今为止，用于生物物质的大量传感器已经使用了高成本的酶固定方法。在这里，报道了具有合成受体功能的高度敏感的基于有机场效应晶体管（OFET）的传感器，该传感器可以选择性地检测乙酰胆碱（ACh（+）），这是与神经刺激传递有关的关键离子。葫芦[6]尿素（CB [6]）衍生物过烯丙氧基CB [6]（（烯丙氧基）（12）CB [6]，AOCB [6]）可溶于甲醇，但不溶于水作为选择性传感层沉积在水稳定的p沟道半导体上的5,5-双-（7-十二烷基-9H-芴-2-基）-2,2-联噻吩层。基于OFET的传感器的检测限低至ACh（+）的1 x 10（-12）m，这比基于离子选择电极的传感器的检测限低六个数量级。此外，这些基于OFET的传感器显示出对胆碱（Ch（+））的ACh（+）具有高度选择性。这些发现证明了一种高灵敏度和高选择性的基于OFET的生物传感器制造的可行方法，并允许将OFETs用作生物物质的高性能传感器的实际应用。

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  • 来源
    《Advanced Functional Materials》 |2015年第30期|4882-4888|共7页
  • 作者

    Jang Moonjeong; Kim Hyoeun; Lee Sunri; Kim Hyun Woo; Khedkar Jayshree K.; Rhee Young Min; Hwang Ilha; Kim Kimoon; Oh Joon Hak;

  • 作者单位

    Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, Gyeongbuk, South Korea|Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Ulsan 689798, South Korea;

    Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, Gyeongbuk, South Korea;

    Pohang Univ Sci & Technol, Div Adv Mat Sci, Pohang 790784, Gyeongbuk, South Korea;

    Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 790784, Gyeongbuk, South Korea;

    Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 790784, Gyeongbuk, South Korea;

    Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 790784, Gyeongbuk, South Korea|Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, Gyeongbuk, South Korea;

    Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 790784, Gyeongbuk, South Korea;

    Pohang Univ Sci & Technol, Div Adv Mat Sci, Pohang 790784, Gyeongbuk, South Korea|Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 790784, Gyeongbuk, South Korea|Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, Gyeongbuk, South Korea;

    Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, Gyeongbuk, South Korea;

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  • 关键词

    acetylcholine; biosensors; organic electronics; transistors; sensitivity;

    机译：乙酰胆碱;生物传感器;有机电子;晶体管;敏感性;

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