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首页> 外文期刊>Advanced Functional Materials >A Shape-Adaptive, Antibacterial-Coating of Immobilized Quaternary-Ammonium Compounds Tethered on Hyperbranched Polyurea and its Mechanism of Action
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A Shape-Adaptive, Antibacterial-Coating of Immobilized Quaternary-Ammonium Compounds Tethered on Hyperbranched Polyurea and its Mechanism of Action

机译：固定在超支化聚脲上的固定化季铵化合物的形状适应性抗菌涂层及其作用机理

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摘要

Quaternary-ammonium-compounds are potent cationic antimicrobials used in everyday consumer products. Surface-immobilized, quaternary-ammonium-compounds create an antimicrobial contact-killing coating. We describe the preparation of a shape-adaptive, contact-killing coating by tethering quaternary-ammonium-compounds onto hyperbranched polyurea coatings, able to kill adhering bacteria by partially enveloping them. Even after extensive washing, coatings caused high contact-killing of Staphylococcus epidermidis, both in culture-based assays and through confocal-laser-scanning-microscopic examination of the membrane-damage of adhering bacteria. In culture-based assays, at a challenge of 1600 CFU/cm~2, contact-killing was ＞99.99%. The working-mechanism of dissolved quaternary-ammonium-compounds is based on their interdigitation in bacterial membranes, but it is difficult to envisage how immobilized quaternary-ammonium-molecules can exert such a mechanism of action. Staphylococcal adhesion forces to hyperbranched quaternary-ammonium coatings were extremely high, indicating that quaternary-ammonium-molecules on hyperbranched polyurea partially envelope adhering bacteria upon contact. These lethally strong adhesion forces upon adhering bacteria then cause removal of membrane lipids and eventually lead to bacterial death.
机译：季铵化合物是日常消费产品中使用的强阳离子抗微生物剂。表面固定的季铵化合物可形成抗微生物接触杀灭涂层。我们描述了通过将季铵化合物束缚到超支化聚脲涂层上来制备形状适应性，接触杀灭性涂层的方法，该涂层能够通过部分包裹它们来杀死附着的细菌。即使在彻底清洗后，无论是在基于培养的分析中，还是通过共聚焦激光扫描显微镜检查粘附细菌的膜损伤，涂层都导致表皮葡萄球菌的高度接触性杀伤。在基于培养物的测定中，在1600 CFU / cm〜2的挑战下，接触杀伤率＞ 99.99％。溶解的季铵化合物的工作机理是基于它们在细菌膜中的相互交叉作用，但是很难设想固定化的季铵分子如何发挥这种作用机制。葡萄球菌对超支化季铵涂层的粘附力极高，表明超支化聚脲上的季铵分子在接触时部分包封粘附细菌。这些致命的强大的粘附力会粘附在细菌上，从而导致膜脂的去除，并最终导致细菌死亡。

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  • 来源
    《Advanced Functional Materials》 |2014年第3期|346-355|共10页
  • 作者

    Lia A. T. W. Asri; Mihaela Crismaru; Steven Roest; Yun Chen; Oleksii Ivashenko; Petra Rudolf; Joerg C. Tiller; Henny C. van der Mei; Ton J. A. Loontjens; Henk J. Busscher;

  • 作者单位

    Department of Polymer Chemistry Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4, 9747, AG Groningen, The Netherlands;

    University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

    University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

    University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

    Surfaces and Thin Films Group Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4, 9747 AG, Groningen, The Netherlands;

    Surfaces and Thin Films Group Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4, 9747 AG, Groningen, The Netherlands;

    Biomaterials and Polymer Science Department of Bio- and Chemical Engineering TU Dortmund Emil-Figge-Strasse 66, 44227, Dortmund, Germany;

    University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

    Department of Polymer Chemistry Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4, 9747, AG Groningen, The Netherlands,University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

    University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands;

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