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Enzymatic Writing to Soft Films: Potential to Filter, Store, and Analyze Biologically Relevant Chemical Information

机译：酶法写入软膜：过滤，存储和分析与生物相关的化学信息的潜力

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摘要

Sensor-based chemical analyses commonly enlist either the molecular recognition capabilities of biology (e.g., enzyme biosensors) or advanced information processing algorithms (e.g., the electronic nose). Here, a hybrid approach is proposed in which an enzyme is used to "filter" chemical information and write this information to a film which then serves as a permanent storage medium that can be 'read' repeatedly, interactively, and by multiple sensor modalities. This approach is demonstrated by analyzing common dietary phenols that are reported to offer health benefits. Specifically, the enzyme tyrosinase is used to convert these phenols into reactive quinones that graft (i.e., write) to a chitosan film. Grafting can be detected by optical, mechanical, and electrochemical sensors. Importantly, grafting confers redox activity to the films and this redox activity can be probed interactively by advanced electrochemical methods that allow the intrinsic redox reactivities to be compared, redox interactions to be identified, and biologically relevant redox activities to be examined. The transfer of chemical and biological information to a film is envisioned to provide broader access to the extensive capabilities offered by sensor technologies and signal processing methodologies.
机译：基于传感器的化学分析通常需要生物学的分子识别功能（例如酶生物传感器）或高级信息处理算法（例如电子鼻）。在这里，提出了一种混合方法，其中使用一种酶来“过滤”化学信息并将该信息写入胶片，然后该胶片充当永久性存储介质，可以通过多种传感器方式反复，交互地“读取”。通过分析据报道具有健康益处的常见饮食中的苯酚可以证明这种方法。具体地说，酪氨酸酶用于将这些酚转化为接枝（即写）到壳聚糖膜上的反应性醌。嫁接可以通过光学，机械和电化学传感器进行检测。重要的是，接枝赋予膜氧化还原活性，并且该氧化还原活性可以通过先进的电化学方法进行交互探测，该电化学方法可以比较内在的氧化还原反应性，鉴定氧化还原相互作用以及检查生物学相关的氧化还原活性。可以设想将化学和生物信息转移到胶片上，以提供对传感器技术和信号处理方法所提供的广泛功能的更广泛访问。

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  • 来源
    《Advanced Functional Materials》 |2014年第4期|480-491|共12页
  • 作者

    Yi Liu; Eunkyoung Kim; Morgan E. Lee; Boce Zhang; Yossef A. Elabd; Qin Wang; Ian M. White; William E. Bentley; Gregory F. Payne;

  • 作者单位

    Institute for Bioscience and Biotechnology Research University of Maryland, College Park, MD 20742, USA;

    Institute for Bioscience and Biotechnology Research University of Maryland, College Park, MD 20742, USA,Fischell Department of Bioengineering University of Maryland, College Park, MD 20742, USA;

    Fischell Department of Bioengineering University of Maryland, College Park, MD 20742, USA;

    Department of Nutrition and Food Science University of Maryland College Park, MD 20742, USA;

    Department of Chemical and Biological Engineering Drexel University Philadelphia, Pennsylvania, 19104, USA;

    Department of Nutrition and Food Science University of Maryland College Park, MD 20742, USA;

    Fischell Department of Bioengineering University of Maryland, College Park, MD 20742, USA,Institute for Systems Research University of Maryland College Park, MD 20742, USA;

    Fischell Department of Bioengineering University of Maryland, College Park, MD 20742, USA;

    Institute for Bioscience and Biotechnology Research University of Maryland, College Park, MD 20742, USA,Fischell Department of Bioengineering University of Maryland, College Park, MD 20742, USA;

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