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A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy

机译：一种在光动力疗法中具有优异抗癌性能的超分子光敏剂

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摘要

A supermolecular photosensitizer with excellent anticancer behavior when used for photodynamic therapy (PDT) is fabricated by the incorporation of zinc phthalocyanines (ZnPc) into the gallery of a layered double hydroxide (LDH). The composite material possesses uniform particle size (hydrodynamic diameter ～ 120 nm), and the host-guest and guest-guest interactions result in a high dispersion of ZnPc in a monomeric state in the interlayer region of the LDH matrix, with high singlet oxygen production efficiency. In vitro tests performed with HepG2 cells reveal a satisfactory PDT effectiveness of the ZnPc(1.5%)/LDH composite photosensitizer a cellular damage as high as 85.7% is achieved with a rather low dosage of ZnPc (10 μg/mL). An extraordinarily high specific efficacy is demonstrated (31.59 μg~(-1) (J/cm~2)~(-1)), which is over 185.5% enhancement compared with the previously reported photo-sensitizers under similar test conditions. Furthermore, an in vivo study of the ZnPc(1.5%)/LDH demonstrates excellent PDT performance with an ultra-low dose (0.3 mg/kg) and a low optical fluence rate (54 J/cm~2). In addition, the ZnPc/LDH photosensitizer displays high stability, good biocompatibility, and low cytotoxicity, which would guarantee its practical application. Therefore, this work provides a facile approach for design and fabrication of inorganic-organic supermolecular materials with greatly enhanced anticancer behavior.
机译：通过将酞菁锌（ZnPc）掺入层状双氢氧化物（LDH）的通道中，可以制造出具有优异抗癌性能的超分子光敏剂。该复合材料具有均匀的粒径（流体动力学直径〜120 nm），并且主客体之间的相互作用导致ZnPc以单体状态在LDH基质的夹层区域中高度分散，并产生高单线态氧效率。用HepG2细胞进行的体外测试显示ZnPc（1.5％）/ LDH复合光敏剂具有令人满意的PDT效果，使用相当低剂量的ZnPc（10μg/ mL），细胞损伤率高达85.7％。证明了极高的特异性功效（31.59μg〜（-1）（J / cm〜2）〜（-1）），与先前报道的在类似测试条件下的光敏剂相比，其增效超过185.5％。此外，对ZnPc（1.5％）/ LDH的体内研究表明，超低剂量（0.3 mg / kg）和低光学通量率（54 J / cm〜2）时，PDT性能优异。另外，ZnPc / LDH光敏剂显示出高稳定性，良好的生物相容性和低细胞毒性，这将保证其实际应用。因此，这项工作为无机-有机超分子材料的设计和制造提供了一种简便的方法，具有大大增强的抗癌性能。

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  • 来源
    《Advanced Functional Materials》 |2014年第21期|3144-3151|共8页
  • 作者

    Ruizheng Liang; Rui Tian; Lina Ma; Lele Zhang; Yanli Hu; Jian Wang; Min Wei; Dan Yan; David G. Evans; Xue Duan;

  • 作者单位

    State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029, PR China;

    State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029, PR China;

    Military Institute of Chinese Materia Medica 302th Military Hospital of China Beijing 100039, PR China;

    Military Institute of Chinese Materia Medica 302th Military Hospital of China Beijing 100039, PR China;

    Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety Department of Chemistry Fuzhou University Fujian 350002, PR China;

    Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety Department of Chemistry Fuzhou University Fujian 350002, PR China;

    State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029, PR China;

    Military Institute of Chinese Materia Medica 302th Military Hospital of China Beijing 100039, PR China;

    State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029, PR China;

    State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029, PR China;

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