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Tetrahydro[5]helicene-Based Nanoparticles for Structure-Dependent Cell Fluorescent Imaging

机译：基于四氢[5] ic烯的纳米粒子用于依赖结构的细胞荧光成像

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摘要

Four new fluorescent dyes containing tetrahydro[5]helicene moiety characterized by three-primary emission colors (blue-green-red) are designed and synthesized, and their structures are characterized by NMR, MS, and single crystal X-ray crystallography. Organic nanoparticles based on the fluorescent dyes are then prepared by re-precipitation method, and their photophysical properties are investigated. These nanoparticles retain the strong emissions of the organic dyes, and multicolor nanoparticles were also prepared by simply tuning the ratios of the three-primary colors dyes. These organic nanoparticles exhibit low cytotoxicity, good photostability, and high quantum yields. Moreover, the nanoparticles can also be applied in the cell fluorescence imaging. Especially, it is interestingly found that the stained regions of these nanoparticles from membrane to cytoplasm for HeLa cells show obvious structure-dependent properties. This strategy provides a new perspective to fluorescence probe by molecular design for specific location imaging of living cells.
机译：设计并合成了四种具有四氢[5]螺旋结构的荧光染料，它们具有三基色发射色（蓝绿色-红色），并通过NMR，MS和单晶X射线晶体学对其结构进行了表征。然后通过再沉淀法制备了基于荧光染料的有机纳米粒子，并对其光物理性质进行了研究。这些纳米粒子保留了有机染料的强发射性，并且还可以通过简单地调整三基色染料的比例来制备多色纳米粒子。这些有机纳米颗粒显示出低细胞毒性，良好的光稳定性和高量子产率。此外，纳米颗粒也可以应用于细胞荧光成像。特别是，有趣的是，发现这些纳米颗粒对HeLa细胞从膜到细胞质的染色区域显示出明显的结构依赖性。该策略通过分子设计为活细胞的特定位置成像提供了荧光探针的新视角。

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  • 来源
    《Advanced Functional Materials》 |2014年第28期|4405-4412|共8页
  • 作者

    Meng Li; Li-Heng Feng; Hai-Yan Lu; Shu Wang; Chuan-Feng Chen;

  • 作者单位

    Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences Beijing 100190, China;

    Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190, China;

    University of Chinese Academy of Sciences Beijing 100049, China;

    Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190, China;

    Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences Beijing 100190, China;

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