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首页> 外文期刊>Chemistry of Materials: A Publication of the American Chemistry Society >Near-Infrared Fluorescent Thiol-Organosilica Nanoparticles That Are Functionalized with IR-820 and Their Applications for Long-Term Imaging of in Situ Labeled Cells and Depth-Dependent Tumor in Vivo Imaging
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Near-Infrared Fluorescent Thiol-Organosilica Nanoparticles That Are Functionalized with IR-820 and Their Applications for Long-Term Imaging of in Situ Labeled Cells and Depth-Dependent Tumor in Vivo Imaging

机译：用IR-820官能化的近红外荧光硫醇 - 有机型纳米颗粒及其用于在体内成像中原位标记细胞的长期成像和深度依赖性肿瘤的应用

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摘要

Thiol-organosilica nanoparticles that are internally functionalized with IR-820 (thiol-OS/IR820) were prepared via a one-pot process for near-infrared (NIR) fluorescence in vivo imaging. Thiol-OS/IR820 demonstrated broad-band emissive NIR fluorescence with multiple new fluorescent peaks that differed from those of the IR-820 molecule and upconversion fluorescence originated from thiol-OS. Thiol-OS/IR820 was biocompatible and did not show significant toxicity in vitro and in vivo. We conducted in vivo tracking of in situ labeled cells against subcutaneous xenograft cells. The in vivo imaging showed a migration and an accumulation of the in situ labeled cells to the site of xenograft cells. Then, a reduction of the grafted cells was observed after 3 weeks. Next, we conducted in vivo tumor imaging of a mouse with a subcutaneous xenograft tumor using intravenous administration of thiol-OS/IR820. Using three wavelengths of light emission, depth-dependent NIR fluorescence imaging of a mouse with a subcutaneous xenograft tumor was conducted. The accumulation of particles in the tumor tissue due to the enhanced permeability and retention (EPR) effect was observed depth-dependently. NIR fluorescence in vivo imaging using thiol-OS/IR820 is useful for long-term observation and shows substantial promise for the visualization of novel biological phenomena in vivo.
机译：通过IR-820（硫醇-OS / IR820）内部官能化的硫醇 - 有机族纳米颗粒通过体内成像中的近红外（NIR）荧光而制备。硫醇-OS / IR820展示了具有多个新的荧光峰的宽带发光NIR荧光，其不同于IR-820分子的荧光峰值，并源自硫醇-OS的上转化荧光。硫醇-OS / IR820是生物相容性的，在体外和体内没有显示出显着的毒性。我们以对皮下异种移植细胞的原位标记细胞进行体内跟踪。体内成像显示迁移和原位标记细胞的累积到异种移植细胞位点。然后，3周后观察到接枝细胞的还原。接下来，我们使用静脉施用硫醇-O / IR820，用皮下卵泡移植肿瘤进行小鼠的体内肿瘤成像。使用三个发光的发光，进行与皮下异种移植瘤的小鼠的深度依赖性NIR荧光成像。依照依赖性观察由于增强的渗透性和保留（EPR）效应引起的肿瘤组织中的颗粒的积累。使用硫醇-SO / IR820的体内成像中的NIR荧光可用于长期观察，并显示出在体内新型生物现象的可视化的实质性许可。

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