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Topographically Flat Substrates with Embedded Nanoplasmonic Devices for Biosensing

机译:具有嵌入式纳米等离子体装置的地形平坦基板,用于生物传感

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摘要

The ability to precisely control the topography, roughness, and chemical properties of metallic nanostructures is crucial for applications in plasmonics, nanofluidics, electronics, and biosensing. Here a simple method to produce embedded nanoplasmonic devices that can generate tunable plasmonic fields on ultraflat surfaces is demonstrated. Using a template-stripping technique, isolated metallic nanodisks and wires are embedded in optical epoxy, which is capped with a thin silica overlayer using atomic layer deposition.The top silica surface is topographically flat and laterally homogeneous, providing a uniform, high-quality biocompatible substrate, while the nanoplasmonic architecture hidden underneath creates a tunable plasmonic landscape for optical imaging and sensing. The localized surface plasmon resonance of gold nanodisks embedded underneath flat silica films is used for real-time kinetic sensing of the formation of a supported lipid bilayer and subsequent receptor-ligand binding. Cold nanodisks can also be embedded in elastomeric materials, which can be peeled off the substrate to create flexible plasmonic membranes that conform to non-planar surfaces.
机译:精确控制金属纳米结构的形貌,粗糙度和化学性质的能力对于等离子,纳米流体,电子和生物传感中的应用至关重要。这里展示了一种简单的方法来生产嵌入式纳米等离子设备,该设备可以在超平坦表面上产生可调等离子场。采用模板剥离技术,将隔离的金属纳米盘和金属丝嵌入光学环氧树脂中,并通过原子层沉积法将其覆盖在一层薄薄的二氧化硅覆盖层上,二氧化硅顶部表面在形貌上是平坦的且横向均一的,从而提供了均匀,高质量的生物相容性基板,而隐藏在其下的纳米等离子体结构则为光学成像和传感创造了可调的等离子体景观。嵌入在平坦二氧化硅膜下的金纳米盘的局部表面等离振子共振用于实时动态感测支持的脂质双层的形成以及随后的受体-配体结合。冷的纳米盘也可以嵌入弹性体材料中,然后将其从基材上剥离下来,以形成与非平面表面相适应的柔性等离子膜。

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  • 来源
    《Advanced Functional Materials》 |2013年第22期|2812-2820|共9页
  • 作者单位

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA;

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA,Department of Biomedical Engineering University of Minnesota Twin Cities, MN 55455, USA;

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA;

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA,Department of Biomedical Engineering University of Minnesota Twin Cities, MN 55455, USA;

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA,Department of Biomedical Engineering University of Minnesota Twin Cities, MN 55455, USA;

    Laboratory of Nanostructures and Biosensing Department of Electrical and Computer Engineering University of Minnesota Twin Cities, MN 55455, USA,Department of Biomedical Engineering University of Minnesota Twin Cities, MN 55455, USA,Department of Biophysics and Chemical Biology Seoul National University Seoul, 151-747, Korea;

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