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Ductile Biodegradable Mg-Based Metallic Glasses with Excellent Biocompatibility

机译:具有优异生物相容性的延性可生物降解的镁基金属玻璃

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摘要

Magnesium-based metallic glasses (MMCs) show intriguing potentials for application as implantable biomaterials owing to their disordered atomic structure, good biodegradability, low elastic modulus, high strength, and large elasticity. However, despite of all these advantages, their brittleness is their Achilles' heel, which severely limits their application as biomedical materials. In the current study, a significantly improved ductility of MMCs under bending and tensile loading through minor alloying with rare-earth element ytterbium (Yb) at an atomic concentration of 2 and 4% is reported. The enhanced ductility is attributed to the increased density of shear bands close to fracture end and larger plastic zones on the fracture surface. In comparison with that of Yb-free control, in vitro cell culture study confirms an improved biocompatibility of MMCs alloyed with Yb as determined by MTT, live-dead, and cytoskeleton staining assays, respectively.
机译:镁基金属玻璃(MMCs)由于其无序的原子结构,良好的生物降解性,低弹性模量,高强度和大弹性而具有潜在的作为可植入生物材料的应用潜力。然而,尽管具有所有这些优点,但它们的脆性是其致命弱点,这严重限制了它们作为生物医学材料的应用。在当前的研究中,据报道,通过与稀土元素(Yb)的微量合金化(原子浓度为2%和4%),MMC在弯曲和拉伸载荷下的延展性得到了显着改善。延展性的提高归因于靠近断裂端的剪切带密度的增加以及断裂面上较大的塑性区。与无Yb对照相比,体外细胞培养研究证实,分别通过MTT,活死和细胞骨架染色测定,与Yb合金化的MMC的生物相容性得到改善。

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  • 来源
    《Advanced Functional Materials》 |2013年第38期|4793-4800|共8页
  • 作者单位

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan,Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203, China;

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan;

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan;

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan;

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan,Department of Chemistry Hong Kong University of Science and Technology Hong Kong SAR, China;

    WPI Advanced Institute of Materials Research Tohoku University Sendai 980-8577, Japan,Department of Materials Science and Engineering University of Wisconsin-Madison 1509 University Avenue Madison, WI 53706, USA;

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