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首页> 外文期刊>Advanced Functional Materials >Protein/Polymer-Based Dual-Responsive Gold Nanoparticles with pH-Dependent Thermal Sensitivity
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Protein/Polymer-Based Dual-Responsive Gold Nanoparticles with pH-Dependent Thermal Sensitivity

机译：基于蛋白质/聚合物的双响应金纳米颗粒，具有pH依赖的热敏性

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摘要

This article presents the synthesis and physicochemical behavior of dualresponsive plasmonic nanoparticles with reversible optical properties based on protein-coated gold nanoparticles grafted with thermosensitive polymer brushes by means of surface-initiated atom transfer radical polymerization (SI-ATRP) that exhibit pH-dependent thermo-responsive behavior. Spherical gold NPs of two different sizes (15 nm and 60 nm) and with different stabilizing agents (citrate and cetyltrimethylammonium bromide (CTAB), respectively) were first capped with bovine serum albumin (BSA). The resulting BSA-capped NPs (Au@BSA NPs) exhibited not only extremely high colloidal stability under physiological conditions, but also a reversible U-shaped pHresponsive behavior, similar to pure BSA. The e-amine of the L-lysine in the protein coating was then used to covalently bind an ATRP-initiator, allowing for the SI-ATRP of thermosensitive polymer brushes of oligo(ethylene glycol) methacrylates with an LCST of 42 ℃ in pure water and around 37 ℃ under physiological conditions. Such protein coated nanoparticles grafted with thermosensitive polymers exhibit a smart pH-dependent thermosensitive behavior.
机译：本文介绍了具有可逆光学特性的双响应等离激元纳米粒子的合成和理化行为，该纳米粒子是通过表面引发的原子转移自由基聚合（SI-ATRP）结合具有热敏性聚合物刷的蛋白质涂层金纳米粒子而呈现出来的，pH-依赖于热反应行为。首先用牛血清白蛋白（BSA）覆盖两种不同大小（15 nm和60 nm）且具有不同稳定剂（分别为柠檬酸盐和十六烷基三甲基溴化铵（CTAB））的球形金纳米颗粒。所得的BSA封端的NPs（Au @ BSA NPs）不仅在生理条件下表现出极高的胶体稳定性，而且还具有类似于纯BSA的可逆U形pH响应行为。然后使用蛋白涂层中L-赖氨酸的e-胺共价键合ATRP引发剂，从而使纯水的LCST为42℃的低聚甲基丙烯酸乙二醇酯（甲基丙烯酸乙二醇酯）热敏聚合物刷的SI-ATRP在生理条件下约37℃。用热敏聚合物接枝的这种蛋白质涂覆的纳米颗粒表现出智能的pH依赖性热敏行为。

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  • 来源
    《Advanced Functional Materials》 |2012年第7期|p.1436-1444|共9页
  • 作者

    Malte S. Strozyk; Munish Chcmana; Isabel Pastoriza-Santos; Jorge Perez-Juste; Luis M. Liz-Marzdn;

  • 作者单位

    Departamento de Quimica Fisica Universidade de Vigo Campus Universitario 36310, Vigo, Spain;

    Departamento de Quimica Fisica Universidade de Vigo Campus Universitario 36310, Vigo, Spain;

    Departamento de Quimica Fisica Universidade de Vigo Campus Universitario 36310, Vigo, Spain;

    Departamento de Quimica Fisica Universidade de Vigo Campus Universitario 36310, Vigo, Spain;

    Departamento de Quimica Fisica Universidade de Vigo Campus Universitario 36310, Vigo, Spain;

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