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首页> 外文期刊>Advanced Functional Materials >Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch
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Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch

机译：基于热敏水凝胶作为控制开关的发光摇铃型介孔二氧化硅微球的多功能药物载体的设计与合成

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摘要

A novel approach for the fabrication of multifunctional microspheres inte grating several advantages of mesoporous, luminescence, and temperature responses into one single entity is reported. First, the hollow mesopo rous silica capsules are fabricated via a sacrificial template route. Then, Gd_2O_3:Eu~(3+) luminescent nanoparticles are incorporated into the internal cavities to form rattle-type mesoporous silica nanocapsules by an incipient wetness impregnation method. Finally, the rattle-type capsules serve as a nanoreactor for successfully filling temperature-responsive hydrogel via photoinduced polymerization to form the multifunctional composite micro spheres. The organic-inorganic hybrid microspheres show a red emission under UV irradiation due to the luminescent Cd_2O_3:Eu~(3+) core. The in vitro cytotoxicity tests show that the samples have good biocompatibility, which indicates that the nanocomposite could be a promising candidate for drug delivery. In addition, flow cytometry and confocal laser scanning microscopy (CLSM) confirm that the sample can be effectively taken up by SKOV3 cells. For in vitro magnetic resonance imaging (MRI), the sample shows the prom ising spin-lattice relaxation time (T_1) weighted effect and could potentially apply as a T_1-positive contrast agent. This composite drug delivery system (DDS) provides a positive temperature controlled "on-oflP'drug release pat tern and the drug, indomethacin (IMC), is released fast at 45 ℃ (on phase) and completely shut off at 20 ℃ (off phase). Meanwhile Gd_2O_3:Eu~(3+) plays an important role as the luminescent tag for tracking the drug loading and release process by the reversible luminescence quenching and recovery phe nomenon. These results indicate that the obtained multifunctional composite has the potential to be used as a smart DDS for biomedical applications.
机译：报道了一种新型的多功能微球的制备方法，该方法将介孔，发光和温度响应的多个优点整合到一个实体中。首先，中空介孔二氧化硅胶囊是通过牺牲模板路线制造的。然后，通过初期湿润浸渍法将Gd_2O_3：Eu〜（3+）发光纳米粒子掺入内腔中以形成拨浪鼓型介孔二氧化硅纳米胶囊。最后，拨浪鼓型胶囊用作纳米反应器，可通过光诱导聚合反应成功填充温度响应型水凝胶，从而形成多功能复合微球。由于发光的Cd_2O_3：Eu〜（3+）核，有机-无机杂化微球在UV辐射下显示红色发射。体外细胞毒性测试表明样品具有良好的生物相容性，这表明纳米复合材料可能是有希望的药物递送候选者。此外，流式细胞仪和共聚焦激光扫描显微镜（CLSM）证实了SKOV3细胞可以有效地吸收样品。对于体外磁共振成像（MRI），该样品显示出明显的自旋晶格弛豫时间（T_1）加权效应，并可能潜在地用作T_1阳性造影剂。这种复合药物递送系统（DDS）提供了正温度控制的“ on-of-P'药物释放模式，药物消炎痛（IMC）在45℃快速释放（同相）并在20℃完全关闭（关闭同时，Gd_2O_3：Eu〜（3+）作为可逆发光猝灭和回收现象的追踪药物负载和释放过程的发光标签，这些结果表明所获得的多功能复合物具有潜在的化学发光潜力。用作生物医学应用的智能DDS。

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  • 来源
    《Advanced Functional Materials》 |2012年第7期|p.1470-1481|共12页
  • 作者

    Xiaojiao Kang; Ziyong Cheng; Dongmei Yang; Pingan Ma; Mengmeng Shang; Chong Peng; Yunlu Dai; Jun Lin;

  • 作者单位

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, 130022, P. R. China,Graduate University of the Chinese Academy of Sciences Beijing, 100049, P. R. China;

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