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Supercritical CO_2: A Clean and Low Temperature Approach to Blending P_(DL)LA and PEC

机译：超临界CO_2：混合P_（DL）LA和PEC的清洁低温方法

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摘要

The unique combination of the gas like viscosity and liquid like density of supercritical CO_2 (scCO_2) is exploited to blend poly(D,L-lactic acid) (P_(DL)LA) and poly(ethylene glycol) (PEC) at near ambient temperatures. This novel process lowers the polymer blend viscosity and also permits incorporation of thermally and solvent labile protein based drugs. A series of blends are prepared with agitation in scCO_2. Differential scanning calorimetry (DSC) data shows that miscible blends can be produced at moderate temperatures. A surprising region of miscibility is revealed between 8 and 25%w/w PEC. The properties of this miscible region are probed with high pressure parallel plate rheological studies, showing that the viscosity in scCO_2 is directly related to the miscibility. Using the particles from gas saturated solutions (PGSS)method, microparticles of these P_(DL)LA/PEG blends are produced using scCO_2 and it is determined that the yields obtained are proportional to the miscibility of the polymers. Thus scCO_2 provides a unique route to low temperature, solvent free processing that accesses a window of miscibility that has not previously been observed. Finally, DSC analyses of these sprayed microparticles confirm the presence of the same high miscibility region observed in the bulk samples prepared under supercritical conditions.
机译：利用超临界CO_2（scCO_2）的气体粘度和液体密度的独特组合，可在接近环境温度下混合聚（D，L-乳酸）（P_（DL）LA）和聚乙二醇（PEC）温度。这种新颖的方法降低了聚合物共混物的粘度，并且还允许掺入热和溶剂不稳定的蛋白质基药物。在scCO_2中搅拌制备一系列共混物。差示扫描量热法（DSC）数据表明，可在中等温度下生成可混溶的混合物。在8％至25％w / w PEC之间显示出令人惊讶的混溶性区域。通过高压平行板流变学研究探查了该可混溶区域的性质，表明scCO_2中的粘度与可混溶性直接相关。使用来自气体饱和溶液（PGSS）方法的颗粒，使用scCO_2制备了这些P_（DL）LA / PEG共混物的微粒，并确定所得收率与聚合物的可混溶性成正比。因此，scCO_2提供了通往低温，无溶剂工艺的独特途径，该工艺可进入以前从未观察到的可混溶性窗口。最后，对这些喷雾微粒的DSC分析证实了在超临界条件下制备的大量样品中观察到相同的高混溶性区域。

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  • 来源
    《Advanced Functional Materials》 |2012年第8期|p.1684-1691|共8页
  • 作者

    Catherine A. Kelly; Andrew Naylor; Lisbeth Ilium; Kevin M. Shakesheff; Steven M. Howdle;

  • 作者单位

    School of Chemistry University of Nottingham Nottingham, NG7 2RD, UK;

    Critical Pharmaceuticals Ltd., BioCity Pennyfoot Street, Nottingham, NG1 IGF, UK;

    Critical Pharmaceuticals Ltd., BioCity Pennyfoot Street, Nottingham, NG1 IGF, UK;

    School of Pharmacy University of Nottingham Nottingham, NC7 2RD, UK;

    School of Chemistry University of Nottingham Nottingham, NG7 2RD, UK;

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