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Evaluation of the Biocompatibility of PLACL/Collagen Nanostructured Matrices with Cardiomyocytes as a Model for the Regeneration of Infarcted Myocardium

机译：评价PLACL /胶原纳米结构基质与心肌细胞作为梗塞心肌再生的模型

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Pioneering research suggests various modes of cellular therapeutics and biomaterial strategies for myocardial tissue engineering. Despite several advantages, such as safety and improved function, the dynamic myocardial microenvironment prevents peripherally or locally administered therapeutic cells from homing and integrating of biomaterial constructs with the infarcted heart. The myocardial microenvironment is highly sensitive due to the nanoscale cues that it exerts to control bioactivities, such as cell migration, proliferation, differentiation, and angiogenesis. Nanoscale control of cardiac function has not been extensively analyzed in the field of myocardial tissue engineering. Inspired by microscopic analysis of the ventricular organization in native tissue, a scalable in-vitro model of nanoscale poly(L-lactic acid)-co -poly(ε -caprolactone)/collagen biocomposite scaffold is fabricated, with nanofibers in the order of 594 ± 56 nm to mimic the native myocardial environment for freshly isolated cardiomyocytes from rabbit heart, and the specifically underlying extracellular matrix architecture: this is done to address the specificity of the underlying matrix in overcoming challenges faced by cellular therapeutics. Guided by nanoscale mechanical cues provided by the underlying random nanofibrous scaffold, the tissue constructs display anisotropic rearrangement of cells, characteristic of the native cardiac tissue. Surprisingly, cell morphology, growth, and expression of an interactive healthy cardiac cell population are exquisitely sensitive to differences in the composition of nanoscale scaffolds. It is shown that suitable cell-material interactions on the nanoscale can stipulate organization on the tissue level and yield novel insights into cell therapeutic science, while providing materials for tissue regeneration.
机译：开拓性研究提出了用于心肌组织工程的各种细胞治疗方法和生物材料策略。尽管有一些优点，例如安全性和改善的功能，但动态心肌微环境可防止外周或局部给药的治疗细胞归巢和将生物材料构建体与梗死的心脏整合。心肌微环境具有高度的敏感性，这是由于其可控制生物活性，例如细胞迁移，增殖，分化和血管生成的纳米级线索。在心肌组织工程领域尚未广泛分析心脏功能的纳米级控制。通过对天然组织的心室组织进行微观分析的启发，构建了纳米级聚（L-乳酸）-共聚（ε-己内酯）/胶原生物复合支架的可扩展体外模型，其中纳米纤维的数量级为594。 ±56 nm模仿来自兔心脏的新鲜分离的心肌细胞的天然心肌环境，以及特定的基础细胞外基质结构：这样做是为了解决基础基质在克服细胞疗法面临的挑战中的特异性。在潜在的随机纳米纤维支架提供的纳米级机械提示的指导下，组织构建体显示出各向异性的细胞重排，这是天然心脏组织的特征。令人惊讶地，交互式健康心脏细胞群的细胞形态，生长和表达对纳米级支架的组成差异非常敏感。结果表明，纳米级的合适细胞-材料相互作用可以规定组织水平上的组织，并为细胞治疗科学提供新的见解，同时为组织再生提供材料。

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  • 来源
    《Advanced Functional Materials》 |2011年第12期|p.2291-2300|共10页
  • 作者

    Shayanti Mukherjee; Jayamma Reddy Venugopal; Rajeswari Ravichandran; Seeram Ramakrishna; Michael Raghunath;

  • 作者单位

    Division of Bioengineering 9 Engineering Drive 1, Block EA #03-12 National University of Singapore, Singapore,HEM laboratory Nanoscience and Nanotechnology Initiative c/o Faculty of Engineering Block E3-05-29, 2 Engineering Drive 3, National University of Singapore Singapore;

    HEM laboratory Nanoscience and Nanotechnology Initiative c/o Faculty of Engineering Block E3-05-29, 2 Engineering Drive 3, National University of Singapore Singapore;

    Department of Mechanical Engineering 9 Engineering Drive 1, Block EA, 07-08 National University of Singapore, Singapore;

    HEM laboratory Nanoscience and Nanotechnology Initiative c/o Faculty of Engineering Block E3-05-29, 2 Engineering Drive 3, National University of Singapore Singapore,Department of Mechanical Engineering 9 Engineering Drive 1, Block EA, 07-08 National University of Singapore, Singapore,Institute of Materials Research and Engineering A-Star, Singapore;

    Division of Bioengineering 9 Engineering Drive 1, Block EA #03-12 National University of Singapore, Singapore,Department of Biochemistry Medical Drive Block MD7, #02-03, Yong Loo Lin School of Medicine National University of Singapore, Singapore;

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