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首页> 外文期刊>Advanced Functional Materials >Near-infra Red Mesoporous Silica Nanoparticles For Optical Imaging: Characterization And In Vivo Biodistribution
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Near-infra Red Mesoporous Silica Nanoparticles For Optical Imaging: Characterization And In Vivo Biodistribution

机译：用于光学成像的近红外中孔二氧化硅纳米粒子：表征和体内生物分布。

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摘要

The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN functionalized with NIR-ICG capable of optical imaging in vivo.
机译：提出了适用于体内光学成像的高效近红外（NIR）介孔二氧化硅纳米粒子（MSN）的表征。通过将TA基团掺入MSN的框架中，合成了平均大小为50-100 nm的三甲基铵基修饰的MSN（MSN-TA）。它通过静电吸引作用进一步被吲哚菁绿（ICG）吸附，从而使MSN-TA-ICG成为用于体内光学成像的有效NIR造影剂。关于MSN-TA-ICG对pH的稳定性的研究表明，该键在从酸性pH到生理pH的范围内均稳定。 MSN-TA-ICG在麻醉大鼠中的体内生物分布显示了在肝脏器官中突出的MSN-TA-ICG相当强而稳定的荧光。硅的透射电子显微镜（TEM）成像和元素分析进一步显示了MSN-TA-ICG在主要器官中的物理和定量驻留。这是用能够在体内进行光学成像的NIR-ICG功能化的MSN的首次报道。

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