• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Random Copolymer Films with Molecular-Scale Compositional Heterogeneities that Interfere with Protein Adsorption
【24h】

Random Copolymer Films with Molecular-Scale Compositional Heterogeneities that Interfere with Protein Adsorption

机译：分子尺度组成异质性干扰蛋白质吸附的无规共聚物薄膜

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Smooth surfaces with compositional heterogeneities at a molecular-length scale are presented with the goal of disrupting surface-protein interactions. These surfaces are synthesized by utilizing photoinitiated chemical vapor deposition (piCVD) to deposit thin films of random copolymers consisting of highly hydrophilic and highly hydrophobic comonomers. Swellability, wettability, and surface roughness could be systematically controlled by tuning the copolymer composition. The surface composition was dynamic, and the surface reconstructed based on the hydration state of the film. Proteins adsorbed to the copolymer films less readily than to either of the respective homopolymers, indicating a synergistic effect resulting from the random copolymer presenting molecular-scale compositional heterogeneity. These results provide direct evidence that protein adsorption can be disrupted by such surfaces and a simple analytical model suggests that the heterogeneities occur over areas encompassing 4-5 repeat units of the polymer. The synthetic method used to create these films can be used to coat arbitrary geometries, enabling practical utility in a number of applications.
机译：提出了在分子长度尺度上具有组成异质性的光滑表面，目的是破坏表面蛋白相互作用。这些表面是通过利用光引发化学气相沉积（piCVD）沉积由高亲水性和高疏水性共聚单体组成的无规共聚物薄膜而合成的。溶胀性，润湿性和表面粗糙度可以通过调节共聚物组成来系统地控制。表面组成是动态的，并且根据膜的水合状态重建了表面。与相应的均聚物相比，蛋白质更不容易吸附到共聚物膜上，表明由无规共聚物表现出分子级组成异质性的协同作用。这些结果提供了直接的证据，表明蛋白质的吸附会被此类表面破坏，并且简单的分析模型表明，异质性发生在包含4-5个聚合物重复单元的区域上。用于制造这些薄膜的合成方法可用于涂覆任意几何形状，从而在许多应用中具有实用性。

著录项

  • 来源
    《Advanced Functional Materials》 |2009年第21期|3489-3496|共8页
  • 作者

    Salmaan H. Baxamusa; Karen K. Gleason;

  • 作者单位

    Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA);

    Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA);

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号