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Neural Networks Grown on Organic Semiconductors

机译：基于有机半导体的神经网络

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We report adhesion, growth, and differentiation of mouse neural cells on ultra-thin films of an organic semiconductor, pentacene. We demonstrate that ⅰ) pentacene is structurally and morphologically stable upon prolonged contact with water, physiological buffer, and cell culture medium; ⅱ) neural stem cells adhere to pentacene and remain viable on it for at least 15 days; ⅲ) densely interconnected neural networks and glial cells develop on the pentacene surface after several days. This implies that adhesion proteins secreted by the cells find suitable adsorption loci to anchor the cells. Pentacene is also a suitable substrate for casting thin layers of cell adhesion molecules, such as laminin and poly-L-lysine. Our results show that pentacene, albeit being an aromatic molecule, allows neurons to adhere to and grow on it, which is possibly due to its tightly packed solid state structure. This structure remains unaltered upon exposure to water and interfacial force exerted by the cells. The integration of living cells into organic semiconductors is an important step towards the development of bio-organic electronic transducers of cellular signals from neural networks.
机译：我们报告有机半导体，并五苯超薄膜上的小鼠神经细胞的粘附，生长和分化。我们证明ⅰ）并五苯与水，生理缓冲液和细胞培养基长时间接触后在结构和形态上是稳定的； ⅱ）神经干细胞粘附并五苯并在其上存活至少15天； ⅲ）数天后，并五苯表面上形成了紧密互连的神经网络和神经胶质细胞。这意味着细胞分泌的粘附蛋白找到合适的吸附基因座来锚定细胞。并五苯也是用于浇铸薄层细胞粘附分子（例如层粘连蛋白和聚L-赖氨酸）的合适基质。我们的结果表明，并五苯尽管是一种芳香分子，但仍允许神经元附着并在其上生长，这可能是由于其紧密堆积的固态结构所致。暴露于水和细胞施加的界面力后，该结构保持不变。将活细胞整合到有机半导体中是朝着神经网络细胞信号的生物有机电子换能器发展的重要一步。

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