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首页> 外文期刊>Advanced Functional Materials >Synthesis of amphiphilic copolymers of poly(ethylene oxide) and poly(epsilon-caprolactone) with different architectures, and their role in the preparation of stealthy nanoparticles
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Synthesis of amphiphilic copolymers of poly(ethylene oxide) and poly(epsilon-caprolactone) with different architectures, and their role in the preparation of stealthy nanoparticles

机译：具有不同结构的聚环氧乙烷和聚ε-己内酯两亲共聚物的合成及其在制备隐形纳米粒子中的作用

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摘要

Well-defined copolymers of biocompatible poly(epsilon-caprolactone) (PCL) and poly(ethylene oxide) (PEO) are synthesized by two methods. Graft copolymers with a gradient structure are prepared by ring-opening copolymerization of epsilon-caprolactone (FCL) with a PEO macromonomer of the epsilon CL-type. The epsilon CL polymerization is initiated by a PEO macroinitiator to prepare diblock copolymers. These amphiphilic copolymers are used as stabilizers for biodegradable poly(DL-lactide) (PLA) nanoparticles prepared by a nanoprecipitation technique. The effect of the copolymer characteristic features (architecture, composition, and amount) on the nanoparticle formation and structure is investigated. The average size, size distribution, and stability of aqueous suspensions of the nanoparticles is measured by dynamic light scattering. For comparison, an amphiphilic random copolymer, poly(methyl methacrylate-co-methacrylic acid) (P(MMA-co-MA)), is synthesized. The stealthiness of the nanoparticles is analyzed in relation to the copolymer used as stabilizer. For this purpose, the activation of the complement system by nanoparticles is investigated in vitro using human serum. This activation is much less important whenever the nanoparticles are stabilized by a PEO-containing copolymer rather than by the P(MMA-co-MA) amphiphile. The graft copolymers with a gradient structure and the diblock copolymers with similar macromolecular characteristics (molecular weight and hydrophilicity) are compared on the basis of their capacity to coat PLA nanoparticles and to make them stealthy.
机译：通过两种方法合成了具有良好生物相容性的聚ε-己内酯（PCL）和聚环氧乙烷（PEO）的共聚物。通过将ε-己内酯（FCL）与εCL型PEO大分子单体开环共聚，可以制备具有梯度结构的接枝共聚物。由PEO大分子引发剂引发εCL聚合反应以制备二嵌段共聚物。这些两亲共聚物用作通过纳米沉淀技术制备的可生物降解的聚（DL-丙交酯）（PLA）纳米粒子的稳定剂。研究了共聚物特性特征（结构，组成和数量）对纳米颗粒形成和结构的影响。纳米粒子的水悬浮液的平均尺寸，尺寸分布和稳定性通过动态光散射来测量。为了进行比较，合成了两亲无规共聚物聚（甲基丙烯酸甲酯-共-甲基丙烯酸）（P（MMA-共-MA））。针对用作稳定剂的共聚物分析了纳米颗粒的隐身性。为此，在体外使用人血清研究了纳米颗粒对补体系统的激活作用。每当纳米颗粒通过含PEO的共聚物而不是通过P（MMA-co-MA）两亲物稳定时，这种活化作用就不那么重要了。根据它们涂覆PLA纳米颗粒并使其隐形的能力，对具有梯度结构的接枝共聚物和具有类似大分子特性（分子量和亲水性）的二嵌段共聚物进行了比较。

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