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Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

机译：光声成像：造影剂及其生物医学应用

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摘要

Photoacoustic (PA) imaging as a fast-developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light-absorption coefficient of the imaged tissue and the injected PA-imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA-imaging contrast agents are developed to improve the PA-imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold-nanocrystal assembly, transition-metal chalcogenides/MXene-based nanomaterials, carbon-based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA-imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA-imaging contrast agents and their significance in biomedical research is presented.
机译：作为一种快速发展的成像技术，光声（PA）成像在生物医学和临床应用中具有巨大的潜力。这是一种非侵入性成像方式，取决于被成像组织和所注入的PA成像造影剂的光吸收系数。此外，PA成像通过检测声波来构建PA图像，从而提供了出色的对比度，超高的空间分辨率以及对组织功能特性的高穿透性和敏感性。近年来，开发了一系列PA成像造影剂，以改善生物医学应用中的PA成像性能。在此，概述了PA造影剂及其生物医学应用的最新进展。 PA造影剂按其成分和功能分类，包括金纳米晶体，金纳米晶体组件，过渡金属硫族化物/基于Mxene的纳米材料，碳基纳米材料，其他无机显像剂，有机小分子，半导体聚合物纳米颗粒和讨论了非线性PA成像造影剂。讨论了PA造影剂作为生物传感器的应用（在金属离子，pH，酶，温度，低氧，活性氧和活性氮的感测中）和在生物成像（淋巴结，脉管系统，肿瘤和脑组织）中的应用。详细。最后，对PA成像造影剂的未来研究和研究前景及其在生物医学研究中的意义进行了展望。

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  • 来源
    《Advanced Materials》 |2019年第6期|1805875.1-1805875.31|共31页
  • 作者

    Fu Qinrui; Zhu Rong; Song Jibin; Yang Huanghao; Chen Xiaoyuan;

  • 作者单位

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

    NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    bioimaging; biomedical application; biosensing; contrast agents; photoacoustic imaging;

    机译：生物成像;生物医学应用;生物传感;造影剂;光声成像;

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