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首页> 外文期刊>Advanced Materials >Surfactant-Stripped Micelles for NIR-Ⅱ Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts
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Surfactant-Stripped Micelles for NIR-Ⅱ Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts

机译：通过表面活性剂剥离的胶束，可通过12 cm的乳房组织和整个人类乳房进行NIR-Ⅱ光声成像

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摘要

Surfactant-stripped micelles are formed from a commercially available cyanine fluoroalkylphosphate (CyFaP) salt dye and used for high contrast photoacoustic imaging (PAI) in the second near-infrared window (NIR-II). The co-loading of Coenzyme Q10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability, and results in a peak absorption wavelength in the NIR-II window close to the 1064 nm output of Nd-YAG lasers used for PAI. Aqueous ss-CyFaP dispersions exhibit intense NIR-II optical absorption, calculated to be greater than 500 at 1064 nm. ss-CyFaP is detected through 12 cm of chicken breast tissue with PAI. In preclinical animal models, ss-CyFaP is visualized in draining lymph nodes of rats through 3.1 cm of overlaid chicken breast tissue. Following intravenous administration, ss-CyFaP accumulates in neoplastic tissues of mice and rats bearing orthotopic mammary tumors without observation of acute toxic side effects. ss-CyFaP is imaged through whole compressed human breasts in three female volunteers at depths of 2.6-5.1 cm. Taken together, these data show that ss-CyFaP is an accessible contrast agent for deep tissue PAI in the NIR-II window.
机译：表面活性剂剥离的胶束由可商购的花菁氟烷基磷酸酯（CyFaP）盐染料形成，并用于第二个近红外窗口（NIR-II）中的高对比度光声成像（PAI）。将辅酶Q10共加载到表面活性剂剥离的CyFaP（ss-CyFaP）胶束中，可提高产量，储存稳定性，并在NIR-II窗口中产生接近于用于Nd-YAG激光器的1064 nm输出的峰值吸收波长PAI。 ss-CyFaP水性分散体表现出强烈的NIR-II光学吸收，在1064 nm处的吸光度大于500。 ss-CyFaP通过PAI在12厘米的鸡胸组织中检测到。在临床前动物模型中，ss-CyFaP通过3.1厘米覆盖的鸡胸组织在引流大鼠的淋巴结中可见。静脉内给药后，ss-CyFaP在患有原位乳腺肿瘤的小鼠和大鼠的肿瘤组织中蓄积，而未观察到急性毒性副作用。 ss-CyFaP通过三名女性志愿者的整个受压人的乳房成像，深度为2.6-5.1 cm。综上所述，这些数据表明，ss-CyFaP是在NIR-II窗口中可用于深层组织PAI的造影剂。

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