...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Materials >Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy
【24h】

Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy

机译：双重肿瘤内氧化还原/酶响应性NO释放纳米药物，用于特异性，高效和低毒癌症治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemotherapy suffers numbers of limitations including poor drug solubility, nonspecific biodistribution, and inevitable adverse effects on normal tissues. Tumor-targeted delivery and intratumoral stimuli-responsive release of drugs by nanomedicines are considered to be highly promising in solving these problems. Compared with traditional chemotherapeutic drugs, high concentration of nitric oxide (NO) exhibits unique anticancer effects. The development of tumor-targeting and intratumoral microenvironment-responsive NO-releasing nanomedicines is highly desired. Here a novel kind of organic-inorganic composite nanomedicine (QM-NPQ@PDHNs) is presented by encapsulating a glutathione S-transferases (GST)-responsive drug O-2-(2,4-dinitro-5-{[2-(-d-galactopyranosyl olean-12-en-28-oate-3-yl)-oxy-2-oxoethyl] piperazine-1-yl} phenyl) 1-(methylethanolamino)diazen-1-ium-1,2-dilate (NPQ) as NO donor and an aggregation-induced-emission (AIE) red fluorogen QM-2 into the cores of the hybrid nanomicelles (PEGylated disulfide-doped hybrid nanocarriers (PDHNs)) with glutathione (GSH)-responsive shells. The QM-NPQ@PDHN nanomedicine is able to respond to the intratumoral over-expressed GSH and GST, resulting in the responsive biodegradation of the protective organosilica shell and NPQ release, and subsequent NO release within the tumor, respectively, and thus normal organs remain unaffected. This work demonstrates a paradigm of dual intratumoral redox/enzyme-responsive NO-release nanomedicine for tumor-specific and high-efficacy cancer therapy.
机译：化学疗法受到许多限制，包括药物溶解性差，非特异性生物分布以及对正常组织不可避免的不利影响。纳米药物对肿瘤的靶向递送和肿瘤内刺激响应性释放被认为在解决这些问题方面非常有前途。与传统的化疗药物相比，高浓度的一氧化氮（NO）表现出独特的抗癌作用。非常需要开发靶向肿瘤和肿瘤内微环境反应性的释放NO的纳米药物。在这里通过封装谷胱甘肽S转移酶（GST）响应药物O-2-（2,4-dinitro-5-{[2-（ -d-galactopyranosyl olean-12-en-28-oate-3-yl）-oxy-2-oxoethyl]哌嗪-1-基}苯基）1-（甲基乙醇氨基）重氮-1-1,2-二磺酸盐（ NPQ）作为NO供体，并向谷胱甘肽（GSH）响应壳的杂化纳米胶束（PEG化二硫键杂化杂化纳米载体（PDHN））的核中聚集诱导发射（AIE）红色荧光QM-2。 QM-NPQ @ PDHN纳米药物能够对肿瘤内过表达的GSH和GST作出反应，导致保护性有机硅壳的响应性生物降解和NPQ释放，以及随后在肿瘤内的NO释放，因此仍然保留了正常器官不受影响。这项工作证明了双重肿瘤内氧化还原/酶反应性NO释放纳米药物的范例，用于肿瘤特异性和高效癌症治疗。

著录项

  • 来源
    《Advanced Materials》 |2018年第30期|1704490.1-1704490.9|共9页
  • 作者

    Jia Xiaobo; Zhang Yihua; Zou Yu; Wang Yao; Niu Dechao; He Qianjun; Huang Zhangjian; Zhu Weihong; Tian He; Shi Jianlin; Li Yongsheng;

  • 作者单位

    East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;

    China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China;

    China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China;

    East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;

    Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Peoples R China;

    China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China;

    East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    dual-responsiveness; nitric oxide; prodrug delivery; safe treatment; tumor therapy;

    机译：双重反应;一氧化氮;前药输送;安全治疗;肿瘤治疗;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号