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首页> 外文期刊>Advanced Materials >Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis
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Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis

机译：在蛋白质颗粒支架上合成的超顺磁性金纳米颗粒用于癌症的治疗。

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摘要

Cancer theragnosis using a single multimodality agent is the next mainstay of modern cancer diagnosis, treatment, and management, but a clinically feasible agent with in vivo cancer targeting and theragnostic efficacy has not yet been developed. A new type of cancer theragnostic agent is reported, based on gold magnetism that is induced on a cancer-targeting protein particle carrier. Superparamagnetic gold-nanoparticle clusters (named SPAuNCs) are synthesized on a viral capsid particle that is engineered to present peptide ligands targeting a tumor cell receptor (TCR). The potent multimodality of the SPAuNCs is observed, which enables TCR-specific targeting, T-2-weighted magnetic resonance imaging, and magnetic hyperthermia therapy of both subcutaneous and deep-tissue tumors in live mice under an alternating magnetic field. Furthermore, it is analytically elucidated how the magnetism of the SPAuNCs is sufficiently induced between localized and delocalized spins of Au atoms. In particular, the SPAuNCs show excellent biocompatibility without the problem of in vivo accumulation and holds promising potential as a clinically effective agent for cancer theragnosis.
机译：使用单一的多模态药物进行癌症恶性肿瘤治疗是现代癌症诊断，治疗和管理的下一个主要手段，但是尚未开发出具有体内靶向癌症和恶性肿瘤治疗功效的临床可行制剂。据报道，基于在靶向癌症的蛋白质颗粒载体上诱导的金磁性，一种新型的癌症治疗剂。超顺磁性金纳米粒子簇（命名为SPAuNCs）是在病毒衣壳颗粒上合成的，该病毒衣壳颗粒经工程设计可提供靶向肿瘤细胞受体（TCR）的肽配体。观察到了SPAuNCs的强大的多模态性，它可以在交变磁场下对活小鼠的皮下和深层组织肿瘤进行TCR特异性靶向，T-2加权磁共振成像和磁热疗。此外，通过分析阐明了如何在Au原子的局部和自旋自旋之间充分感应出SPAuNC的磁性。尤其是，SPAuNCs具有出色的生物相容性，而没有体内积累的问题，并有望作为临床有效的治疗恶性肿瘤的药物。

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