Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

Liu Yu; Kang Ning; Lv Jing; Zhou Zijian; Zhao Qingliang; Ma Lingceng; Chen Zhong; Ren Lei; Nie Liming

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Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

机译：使用高效上变频纳米复合材料在生活对象中进行深光声/发光/磁共振多峰成像

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A gadolinium-doped multi-shell up-conversion nanoparticle under 800 nm excitation is synthesized with a 10-fold fluorescence-intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri-modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at a new imaging depth.

机译：合成了在800 nm激发下掺nano的多壳上转换纳米粒子，其荧光强度比980 nm下增强了10倍。纳米制剂具有出色的光声/发光/磁共振三峰成像功能，可以在新的成像深度下可视化肿瘤形态和微血管分布。

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来源
《Advanced Materials》 |2016年第30期|6411-6419|共9页
作者
Liu Yu; Kang Ning; Lv Jing; Zhou Zijian; Zhao Qingliang; Ma Lingceng; Chen Zhong; Ren Lei; Nie Liming;
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Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen 361102, Peoples R China|Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China;

Xiamen Univ, Coll Mat, Key Lab Fire Retardant Mat, Dept Biomat & Fujian Prov, Xiamen 361005, Peoples R China;

Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China;

Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen 361102, Peoples R China|Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China;

Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen 361102, Peoples R China|Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China;

Xiamen Univ, Coll Phys & Electromech Engn, Dept Elect Sci, Xiamen 361005, Peoples R China;

Xiamen Univ, Coll Phys & Electromech Engn, Dept Elect Sci, Xiamen 361005, Peoples R China;

Xiamen Univ, Coll Mat, Key Lab Fire Retardant Mat, Dept Biomat & Fujian Prov, Xiamen 361005, Peoples R China;

Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen 361102, Peoples R China|Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China;

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专利

1. Multimodal bioimaging using a rare earth doped Gd2O2S:Yb/Er phosphor with upconversion luminescence and magnetic resonance properties [J] . G. Ajithkumar, Benjamin Yoo, Dara E. Goral Journal of Materials Chemistry, B. materials for biology and medicine . 2013,第11期

机译：使用稀土掺杂的Gd2O2S：Yb / Er荧光粉进行多模态生物成像，具有上转换发光和磁共振特性
2. Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects [J] . Anca Dragulescu-Andrasi, Carmel T. Chan, Abhijit De, Proceedings of the National Academy of Sciences of the United States of America . 2011,第29期

机译：生物发光共振能量转移（BRET）成像，用于研究对象深层组织内的蛋白质相互作用
3. Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy [J] . ChengL., YangK., LiY., Biomaterials . 2012,第7期

机译：多功能纳米粒子用于上转换发光/ MR多峰成像和磁性靶向光热疗法
4. Multimodality photoacoustic and Raman imaging of magnetically-trapped tumor cells [C] . Wei Shi, Peng Shao, Robert Paproski, Conference on photons plus ultrasound: imaging and sensing . 2014

机译：磁性捕获肿瘤细胞的多模态光声和拉曼成像
5. Multimodal Magnetic Resonance Image Fusion and Fluorescent Microthermal Imaging of Magnetic Hyperthermia [D] . Zheng, Xiaowan. 2017

机译：磁体热疗的多模式磁共振图像融合与荧光微热成像
6. Multimodal bioimaging using rare earth doped Gd2O2S: Yb/Er phosphor with upconversion luminescence and magnetic resonance properties [O] . G. Ajithkumar, Benjamin Yoo, Dara E. Goral, -1

机译：使用稀土掺杂的Gd2O2S：Yb / Er磷光体的多峰生物成像具有上转换发光和磁共振特性
7. Bioluminescence resonance energy transfer (BRET) imaging of protein–protein interactions within deep tissues of living subjects [O] . Dragulescu-Andrasi, Anca, Chan, Carmel T., De, Abhijit, 2011

机译：生物发光共振能量转移（BRET）成像，用于研究对象深层组织中的蛋白质相互作用

Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

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