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Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

机译:包含细胞毒性T细胞抗原决定簇的自组装肽两亲胶束促进体内保护性免疫反应。

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摘要

There is enormous potential in peptide-based immunotherapy to be effective for both prophylactic vaccines'1'21 and remedial treatments for cancer'3' and autoimmune diseases. Peptides can be designed to contain the minimal amino acid sequences necessary to stimulate an adaptive immune response. However, peptides on their own tend to be weak immunogens and require strong, often toxic, adjuvants to be effective. This limits their use in clinical applications. Effective peptide-based vaccines require peptide delivery systems that can boost peptide-specific immune responses without causing any undesirable side effects. An effective delivery system should concentrate the antigen, protect the antigen from degradation, increase uptake and processing by dendritic cells (DCs), and induce the production of cytokines that create a robust immune response. We propose that peptide amphiphiles (PAs), which self-assemble into nanometer-sized micelles, can meet these requirements for an effective antigen delivery system.
机译:基于肽的免疫疗法对于预防性疫苗'1'21和癌症'3'和自身免疫性疾病的治疗均具有巨大潜力。可以将肽设计为包含刺激适应性免疫应答所需的最小氨基酸序列。然而,肽本身往往是弱免疫原,需要强的,通常是有毒的佐剂才能有效。这限制了它们在临床应用中的使用。有效的基于肽的疫苗需要肽递送系统,该系统可增强肽特异性免疫反应而不会引起任何不良副作用。有效的递送系统应浓缩抗原,保护抗原免于降解,增加树突状细胞(DC)的摄取和加工,并诱导产生可产生强大免疫反应的细胞因子。我们提出自组装成纳米级胶束的肽两亲物(PAs)可以满足有效抗原递送系统的这些要求。

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  • 来源
    《Advanced Materials》 |2012年第28期|p.3845-3849|共5页
  • 作者单位

    Department of Chemical Engineering University of California Santa Barbara, Santa Barbara, CA 93106, USA;

    Biomolecular Science and Engineering Program University of California Santa Barbara, Santa Barbara, CA 93106, USA;

    Department of Bioengineering University of California Berkeley, Berkeley, CA 94709, USA;

    Department of Bioengineering University of California Berkeley, Berkeley, CA 94709, USA;

    Immunity and Vaccinology Laboratory The Queensland Institute of Medical Research Brisbane QLD 4029, Australia;

    Institute for Molecular Engineering University of Chicago Searle Chemistry Laboratory Room 402, 5735 South Ellis Avenue, Chicago, IL 60637, USA;

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  • 入库时间 2022-08-17 13:52:52

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