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首页> 外文期刊>Advanced Materials >Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy
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Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy

机译：基于光敏剂共轭碳点的光触发治疗学方法，用于同时增强荧光成像和光动力疗法

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摘要

Theranostics, combining both medical diagnostics and therapeutics to achieve an optimizing efficacy and safety of comprehensive regime, is an emerging interdiscipline that is paving the avenue towards the goal of personalized medicine. Activatable theranostic agents can enhance the selectivity and specificity for disease destruction with high localized cytotoxicity and little collateral damage. So far, controllable activation by an external stimulus such as temperature, pH, applied magnetic or electrical field, ultrasound, light, or enzymatic action have been proposed as triggered delivery systems. Over the past decade, light-triggered theranostics, such as photodynamic-, photothermal- and photo-triggered chemotherapy have received increased attention due to the advantage of highly specific spatial and temporal control of compound release.The theranostic constructs could advance a novel category of clinical solution which possesses early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy.
机译：治疗学，结合了医学诊断学和治疗学，以实现综合治疗方案的最佳疗效和安全性，是一个新兴的交叉学科，正在朝着个性化医学的目标铺平道路。可活化的治疗药物可提高疾病破坏的选择性和特异性，具有较高的局部细胞毒性和很少的附带损害。迄今为止，已经提出了通过外部刺激例如温度，pH，施加的磁场或电场，超声，光或酶作用的可控激活作为触发递送系统。在过去的十年中，由于对化合物释放的高度特定的时空控制的优势，光触发的治疗学，例如光动力化学疗法，光热疗法和光触发化学疗法受到了越来越多的关注。一种临床解决方案，通过在各种成像方式中增强对比度，然后对治疗进行量身定制的指导，从而具有对该疾病的早期识别。

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  • 来源
    《Advanced Materials》 |2012年第37期|5104-5110|共7页
  • 作者

    Peng Huang; Jing Lin; Xiansong Wang; Zhe Wang; Chunlei Zhang; Meng He; Kan Wang; Feng Chen; Zhiming Li; Cuangxia Shen; Daxiang Cui; Xiaoyuan Chen;

  • 作者单位

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China,Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Institute of Micro-Nano Science and Technology Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai 200240, PR China;

    Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA,Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005, China;

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