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Multicompartment Intracellular Self-Expanding Nanogel for Targeted Delivery of Drug Cocktail

机译：多室细胞内自膨胀纳米凝胶用于靶向药物鸡尾酒的输送

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摘要

The combination of antiretrovirals of different acting mechanisms, known as cocktail therapy, has proven highly effective in suppressing HIV replication and widely used to control the progression of AIDS.[1] Inspired by the success of AIDS treatment, scientists have investigated anticancer drug combinations for the treatment of various types of cancer. [2] Due to the heterogeneity of a tumor, cancer cells exist at different stages in the cell cycle. A drug cocktail, a combination of drugs with different anticancer mechanisms that have specific activity on cells at different growth stages and act synergistically, should exhibit superior response and patient survival rate than any single agent.[3] However, the translation of this theoretical advantage to benefit the patient is hindered by their associated side effects: (i) the potent toxic drug combination can damage normal cells while it kills cancer cells, (ii) the potential drug-drug interaction can deteriorate patient health condition, and (iii) the consequence of side effect results in poor patient compliance.
机译：不同作用机制的抗逆转录病毒药物的组合被称为鸡尾酒疗法，已被证明在抑制HIV复制方面非常有效，并被广泛用于控制AIDS的进展。[1]受艾滋病治疗成功的启发，科学家们研究了抗癌药物组合用于治疗各种类型的癌症。 [2]由于肿瘤的异质性，癌细胞存在于细胞周期的不同阶段。药物混合物是一种具有不同抗癌机制的药物的组合，在不同的生长阶段对细胞具有特定的活性，并具有协同作用，应该比任何一种药物都具有更好的反应和患者的存活率。[3]但是，这种理论上的好处使患者受益的转化受到其相关的副作用的阻碍：（i）有效的有毒药物组合可以在杀死癌细胞的同时损害正常细胞，（ii）潜在的药物相互作用可能会使患者恶化健康状况；以及（iii）副作用导致患者依从性差。

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  • 来源
    《Advanced Materials》 |2012年第48期|6479-6483|共5页
  • 作者

    Remant Bahadur K. C.; Peisheng Xu;

  • 作者单位

    Department of Pharmaceutical and Biomedical Sciences South Carolina College of Pharmacy University of South Carolina 715 Sumter, Columbia, SC 29208, USA;

    Department of Pharmaceutical and Biomedical Sciences South Carolina College of Pharmacy University of South Carolina 715 Sumter, Columbia, SC 29208, USA,Nanocenter and Center for Colon Cancer Research University of South Carolina 712 Main Street, Columbia, SC 29208, USA;

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