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Bone-like Resorbable Silk-based Scaffolds For Load-bearing Osteoregenerative Applications

机译：用于承重骨再生应用的骨样可吸收丝基脚手架

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The relative paucity of techniques currently available to repair bone tissue necessitates the development of innovative and more effective clinical strategies. Of these, the combined integration of macroporous scaffolds, primed human-cell populations, and growth factors to organize and promote tissue formation is a particularly attractive approach. However, bone tissue engineering is currently compromised by its inability to produce load-bearing scaffolds. For example, collagen scaffolds are used for a range of osteogenic applications, but exhibit a compressive strength of ca. 0.034 MPa, approximately three orders of magnitude lower than that of cancellous bone with values between 10 and 50 MPa. On the other hand, pure calcium phosphate mineral-based scaffolds, which currently dominate the commercial bone substitute materials market, lack a fibrillar protein component and are correspondingly brittle, typically failing catastrophically at compressive loads of less than 5 MPa.
机译：当前可用的修复骨组织的技术相对较少，因此需要开发创新且更有效的临床策略。其中，大孔支架，引发的人细胞群体和生长因子的组合整合以组织和促进组织形成是特别有吸引力的方法。但是，骨组织工程目前由于不能生产承重支架而受到损害。例如，胶原蛋白支架被用于一系列成骨性应用，但是表现出约1,1的压缩强度。 0.034 MPa，比松质骨的值低10到50 MPa大约三个数量级。另一方面，目前在商业骨替代材料市场上占主导地位的纯磷酸钙矿物基支架缺乏纤维状蛋白成分，并且相应地易碎，通常在小于5 MPa的压缩载荷下会发生灾难性的破坏。

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