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首页> 外文期刊>Advanced Materials >A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy
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A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy

机译：一种无害的有害的可切换和不间断的漆置于可激活的化学动力治疗的杀手

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摘要

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular hydrogen peroxide (H2O2) into hydroxyl radicals (OH center dot). Although many studies on H2O2 supplementation have been conducted to improve the therapeutic effect of CDT, few studies have focused on the application of superoxide radical (O-2(-center dot)) in CDT, which may result in better efficacy. A major concern about O-2(-center dot)-mediated CDT is its tendency to induce serious oxidative damage to normal tissues, which may be addressed by using a degradable O-2(-center dot) scavenger. Here, a harmless-harmful switchable and uninterrupted laccase (LAC)-instructed killer (HULK) is constructed, which is the first CDT agent accelerated by LAC-instructed O-2(-center dot) generation and possesses a harmless-harmful switchable effect because of the photodegradation of the O-2(-center dot) scavenger iron-chlorin e6 (FeCe6). LAC-instructed substrate oxidation effectively catalyzes O-2(-center dot) production with the help of intracellular reduction, thereby promoting the conversion of Fe3+ to Fe2+, accelerating the generation of OH center dot, and inducing tumor cell apoptosis and necrosis. The introduced O-2(-center dot) scavenger FeCe6 is quickly photodegraded during irradiation, while LAC-instructed O-2(-center dot) generation proceeds as before, resulting in activatable CDT. This work not only provides the first strategy for LAC-instructed O-2(-center dot) generation but also presents new insight into activatable CDT.
机译：化学动力学治疗（CDT）使用FENTON催化剂通过将细胞内氢（H 2 O 2）转化为羟基自由基（OH中心点）来杀死癌细胞。尽管已经进行了许多关于H 2 O 2的研究，以改善CDT的治疗效果，但很少有研究集中在CDT中施用过氧化物自由基（O-2（ - Center Dot）），这可能导致更好的功效。关于O-2（ - 中心点）介导的CDT的主要担忧是其促使对正常组织的严重氧化损伤的趋势，这可以通过使用可降解的O-2（Centor Dot）清除剂来解决。这里，构建无害有害的可切换和不间断的杀酶（LAC） - 阻杀剂（Hulk），这是由Lac指示的O-2（Center Dot）产生的第一CDT剂，并且具有无害有害的可切换效果由于O-2（ - 中心点）清除剂铁氯E6（FECE6）的光降解。 LAC指示的底物氧化有效地催化了偶联的细胞内降低的O-2（Center点）产生，从而促进Fe3 +至Fe2 +的转化率，加速OH中心点的产生，诱导肿瘤细胞凋亡和坏死。引入的O-2（Center Dot）清除剂FECE6在照射期间快速光降解，而LAC指示的O-2（ - Center Dot）的产生如前所述，导致可激活的CDT。这项工作不仅为LAC指示的O-2（Center Dot）代表提供了第一个策略，而且还向可激活的CDT提供了新的洞察力。

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  • 来源
    《Advanced Materials》 |2021年第27期|2100114.1-2100114.11|共11页
  • 作者

    Zhou Tian-Jiao; Xu Yuan; Xing Lei; Wang Yi; Jiang Hu-Lin;

  • 作者单位

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China|China Pharmaceut Univ Jiangsu Key Lab Druggabil Biopharmaceut Nanjing 210009 Peoples R China|China Pharmaceut Univ Jiangsu Key Lab Drug Discovery Metab Dis Nanjing 210009 Peoples R China|China Pharmaceut Univ NMPA Key Lab Res & Evaluat Pharmaceut Preparat & Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China|China Pharmaceut Univ Jiangsu Key Lab Druggabil Biopharmaceut Nanjing 210009 Peoples R China|China Pharmaceut Univ Jiangsu Key Lab Drug Discovery Metab Dis Nanjing 210009 Peoples R China|China Pharmaceut Univ NMPA Key Lab Res & Evaluat Pharmaceut Preparat & Nanjing 210009 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    chemodynamic therapy; iron-chlorin e6; laccase; photodegradation; superoxide radical;

    机译：化学动力学治疗;铁氯E6;漆酶;光降解;超氧化物自由基;

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