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首页> 外文期刊>AIDS Research and Human Retroviruses >Current HIV Type 1 Molecular Epidemiology Profile and Identification of Unique Recombinant Forms in Jakarta, Indonesia
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Current HIV Type 1 Molecular Epidemiology Profile and Identification of Unique Recombinant Forms in Jakarta, Indonesia

机译：印度尼西亚雅加达当前的HIV 1型分子流行病学概况和独特重组形式的鉴定

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摘要

HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted in 2007 in Jakarta. The majority of participants were 16–30 years of age (64.9%) and 74.5% were male. The most frequent risk factor was injecting drug use (IDU) (45.7%) followed by heterosexual transmission (34.1%). Phylogenetic analysis of gag (p17 and p6) and env C2V3 regions showed 200 (96.2%) of 208 DNA samples were CRF01_AE and only 3 (1.4%) were subtype B. Five samples (2.4%) indicated discordant subtypes between the three aforementioned regions: three of them showed unique CRF01_AE/B recombination patterns in 2.3-kbp nucleotide sequences (from p17 to part of RT), including one sample showing similarity to CRF33_01B, reported previously in Malaysia. This study shows the current predominant subtype is CRF01_AE in every risk group, with a decreasing number of pure subtype B, and the first identification of CRF01_AE/B recombinant forms among HIV-1-seropositive Indonesians.
机译：艾滋病毒感染是印度尼西亚的一个主要问题。艾滋病毒感染者的人数逐年增加，特别是在注射吸毒者中。由于印度尼西亚关于艾滋病毒/艾滋病分子流行病学概况的数据有限，因此于2007年在雅加达进行了一项横断面研究，涉及208名HIV-1血清阳性个体。大多数参与者为16至30岁（64.9％），男性为74.5％。最常见的危险因素是注射毒品（IDU）（45.7％），其次是异性传播（34.1％）。对gag（p17和p6）和env C2V3区域进行的系统进化分析显示208个DNA样品中有200个（96.2％）为CRF01_AE，只有3个（1.4％）为B亚型。五个样品（2.4％）表明上述三个区域之间存在不一致的亚型：其中三个在2.3 kbp核苷酸序列（从p17到RT的一部分）中显示出独特的CRF01_AE / B重组模式，包括一个先前与马来西亚报道的显示与CRF33_01B相似的样品。这项研究表明，在每个风险组中，当前的主要亚型是CRF01_AE，纯净的亚型B的数量正在减少，并且在HIV-1血清阳性印度尼西亚人中首次鉴定了CRF01_AE / B重组形式。

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  • 来源
    《AIDS Research and Human Retroviruses》 |2009年第7期|637-646|共10页
  • 作者

    Ivo N. Sahbandar; Kiyomi Takahashi; Zubairi Djoerban; Iman Firmansyah; Satoshi Naganawa; Kazushi Motomura; Hironori Sato; Katsuhiko Kitamura; Herdiman T. Pohan; Shigehiro Sato;

  • 作者单位

    Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.;

    Department of Microbiology, School of Medicine, Iwate Medical University, Morioka, Japan.;

    Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.;

    Sulianti Saroso Infectious Disease Hospital, Jakarta, Indonesia.;

    Yokohama City University School of Medicine, Yokohama, Japan.;

    Center for Genomic Pathogen, National Institute of Infectious Diseases, Tokyo, Japan.;

    Center for Genomic Pathogen, National Institute of Infectious Diseases, Tokyo, Japan.;

    Yokohama City University School of Medicine, Yokohama, Japan.;

    Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.;

    Department of Microbiology, School of Medicine, Iwate Medical University, Morioka, Japan.;

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