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Geographical Hotspots of Extensive Intersubtype Recombination in Asia: 'Melting Pot' That Generates Diverse Forms of HIV-1 Unique Recombinants

机译:亚洲广泛梭织重组的地理热点:“熔炉”,产生不同形式的HIV-1独特的重组剂

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Molecular epidemiological investigation was conducted among high risk populations in two cities (Yangon and Mandalay) in Myanmar and three study sites (Wenshan, Honghe and Dehong) in Yunnan, China. The study identified the unique geographical hotspots in Central Myanmar and Western Yunnan, where diverse forms of recombinant strains appear to be arising continually. This may reflect the presence of highly exposed individuals and social networks in these regions. Precise mapping of recombination breakpoints revealed that significant proportion of unique recombinants found in Central Myanmar shared the breakpoints with CRF07/08_-BC in China, suggesting that they may have been evolved from common ancestral recombinants. This represents the first evidence that may suggest the possible linkage between the epidemics in both regions.
机译:分子流行病学调查是在缅甸的两个城市(仰光和曼德勒)的高风险群体中进行的,三个研究网站(云南,云南,云南,洪河和德河)。该研究确定了中部缅甸和云南西部独特的地理热点,其中各种形式的重组菌株似乎不断地产生。这可能反映了这些地区的高度暴露的个人和社交网络。重组断裂点的精确映射揭示了缅甸中部发现的独特重组分子的显着比例与中国的CRF07 / 08_-o-BC分享了断点,这表明他们可能已经从常见的祖先重组中演变。这代表了可能提出这两个地区的流行病之间可能联系的第一证据。

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