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首页> 外文期刊>AIDS Research and Human Retroviruses >Proliferation and Foxp3 Expression in Virus-Specific Memory CD8+ T Lymphocytes
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Proliferation and Foxp3 Expression in Virus-Specific Memory CD8+ T Lymphocytes

机译：病毒特异性记忆CD8 + T淋巴细胞中的增殖和Foxp3表达。

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Foxp3 plays a critical role in development of CD4+ regulatory T lymphocytes (Tregs). It was originally proposed as a specific marker for Tregs, but recent studies have shown that Foxp3 can be expressed in proliferating CD8+ and CD4+ T lymphocytes. We further investigated the association between Foxp3 expression and proliferation of peripheral blood CD4+ and CD8+ T lymphocytes and focused on virus-specific memory CD8+ T lymphocytes. We found that resting peripheral blood bulk and cytomegalovirus- or HIV-1-specific CD8+ T lymphocytes do not normally express Foxp3. However, stimulation in vitro triggered these cells to express Foxp3 as well as CD25, and the addition of interleukin-2 possibly enhanced the expression of Foxp3. These data demonstrate that proliferation itself is sufficient to induce the Treg-like phenotype. Given that others have demonstrated Treg functional activity in such “induced Tregs,” these results suggest that virus-specific CD8+ T lymphocytes have the capacity to acquire regulatory functions. Although the implications of Foxp3 expression in virus-specific CD8+ T lymphocytes in the immunologic control of persistent HIV-1 viremia remain to be determined, our results are consistent with Foxp3 expression playing an essential role in regulation of cell proliferation and functional outcomes for HIV-1-specific CD8+ T lymphocytes
机译：Foxp3在CD4 +调节性T淋巴细胞（Tregs）的发育中起关键作用。它最初被提议作为Treg的特异性标记，但是最近的研究表明Foxp3可以在增殖的CD8 +和CD4 + T淋巴细胞中表达。我们进一步研究了Foxp3表达与外周血CD4 +和CD8 + T淋巴细胞增殖之间的关联，并集中于病毒特异性记忆CD8 + T淋巴细胞。我们发现静息的外周血和巨细胞病毒或HIV-1特异性CD8 + T淋巴细胞通常不表达Foxp3。但是，体外刺激会触发这些细胞表达Foxp3和CD25，添加白介素2可能会增强Foxp3的表达。这些数据证明增殖本身足以诱导Treg样表型。考虑到其他人已经证明了Treg在这种“诱导的Treg”中的功能活性，这些结果表明病毒特异性CD8 + T淋巴细胞具有获得调节功能的能力。尽管病毒特异性CD8 + T淋巴细胞中Foxp3表达在持续性HIV-1病毒血症的免疫控制中的意义尚待确定，但我们的结果与Foxp3表达在调节细胞增殖和HIV- 1-特异性CD8 + T淋巴细胞

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