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首页> 外文期刊>Air quality, atmosphere & health >Increased cardiovascular risk in association with chronic airflow obstruction among premenopausal rural women of India who cook exclusively with biomass
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Increased cardiovascular risk in association with chronic airflow obstruction among premenopausal rural women of India who cook exclusively with biomass

机译：印度绝经前农村仅用生物质烹饪的妇女中，与慢性气流阻塞相关的心血管风险增加

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We aimed to compare the cardiovascular risk in biomass-using women with or without chronic obstructive pulmonary disease (COPD). A total of 22 biomass-using married women with COPD and 24 matched controls with normal lung function were enrolled for this purpose. Platelet P-selectin (P-sel) expression and platelet–leukocyte aggregation were determined using flow cytometry. Platelet aggregation by collagen was measured by aggregometer. Soluble P-selectin (sP-sel), tumor necrosis factor-alpha (TNF-α), interleukin-8, -6, -10 (IL-8, IL-6, IL-10), neutrophil-activating protein-2 (NAP-2), C-reactive protein (CRP), oxidized low density lipoprotein (oxLDL) in plasma were measured by enzyme-linked immunosorbent assay. Generation of reactive oxygen species (ROS) by leukocytes was measured by flow cytometry, and erythrocyte content of superoxide dismutase (SOD) was measured by spectrophotometry. Particulate matter with a diameter of less than 2.5 μm (PM2.5) in indoor air was measured by real-time aerosol monitor. Compared with control, biomass users with COPD had increased expression of platelet P-selectin, elevated levels of sP-sel, oxLDL, TNF-α, IL-8, IL-6, NAP-2, CRP, lowered IL-10 and more circulating platelet-neutrophil (p < 0.0001) and platelet–monocyte (p < 0.0001) aggregates. ROS generation was increased by 19.5% while SOD was depleted by 32% in women with COPD. Biomass smoke-induced COPD is associated with excess cardiovascular risk via oxidative stress, platelet activation, and inflammation.
机译：我们旨在比较使用或不使用慢性阻塞性肺疾病（COPD）的使用生物质的妇女的心血管风险。为此，共招募了22名COPD使用已婚生物的已婚妇女和24名肺功能正常的配对对照。使用流式细胞仪测定血小板P选择素（P-sel）的表达和血小板白细胞聚集。通过凝集仪测量胶原蛋白引起的血小板聚集。可溶性P-选择素（sP-sel），肿瘤坏死因子-α（TNF-α），白介素8，-6，-10（IL-8，IL-6，IL-10），嗜中性白细胞活化蛋白2用酶联免疫吸附法测定血浆中的NAP-2（NAP-2），C反应蛋白（CRP），氧化型低密度脂蛋白（oxLDL）。通过流式细胞术测量白细胞产生的活性氧（ROS），通过分光光度法测量超氧化物歧化酶（SOD）的红细胞含量。通过实时气溶胶监测仪测量室内空气中直径小于2.5μm（PM2.5）的颗粒物。与对照组相比，患有COPD的生物质使用者的血小板P选择素表达增加，sP-sel，oxLDL，TNF-α，IL-8，IL-6，NAP-2，CRP含量升高，IL-10降低等循环中性粒细胞血小板（p（<0.0001）和血小板单核细胞（p <0.0001）聚集。患有COPD的女性的ROS生成量增加了19.5％，而SOD却减少了32％。生物质烟雾诱导的COPD通过氧化应激，血小板活化和炎症与过度心血管疾病风险相关。

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