Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-na?ve patients with chronic hepatitis C genotype 1

M. Palmer; R. Rubin; V. Rustgi; Taribavirin Viral Kinetic Study Group

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Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-na?ve patients with chronic hepatitis C genotype 1

机译：随机临床试验：在未接受过治疗的慢性丙型肝炎基因型患者中，先使用taribavirin进行聚乙二醇化干扰素与标准联合用药治疗前的剂量

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Combination therapy with the ribavirin (RBV) prodrug taribavirin (TBV) and pegylated interferon (PIFN) has produced lower rates of anaemia than with RBV and PIFN. Studies have demonstrated that the sharpest decline in viral load during TBV therapy occurs at Weeks 4 through 6, when TBV reaches steady-state blood levels.

机译：利巴韦林（RBV）前药，taribavirin（TBV）和聚乙二醇化干扰素（PIFN）的联合治疗产生的贫血发生率低于RBV和PIFN。研究表明，TBV治疗期间病毒载量的最大下降发生在TBV达到稳态血液水平的第4至第6周。

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《Alimentary Pharmacology & Therapeutics》 |2012年第4期|370-378|共9页
作者
M. Palmer; R. Rubin; V. Rustgi; Taribavirin Viral Kinetic Study Group;
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Liver Center of Long Island Plainview NY USA;

Digestive Healthcare of Atlanta Atlanta GA USA;

Metropolitan Research Georgetown Medical Center Fairfax VA USA;

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1. Randomised clinical trial: Pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-na?ve patients with chronic hepatitis C genotype 1 [J] . PalmerM., RubinR., RustgiV. Alimentary pharmacology & therapeutics. . 2012,第4期

机译：随机临床试验：对于初治的慢性丙型肝炎基因1型患者，在开始聚乙二醇干扰素与标准联合用药方案之前先加用他巴韦林
2. Comparison of low-dose pegylated interferon versus standard high-dose pegylated interferon in combination with ribavirin in patients with chronic hepatitis C with genotype 3: an Indian experience. [J] . Sood A, Midha V, Hissar S, Journal of gastroenterology and hepatology . 2008,第2期

机译：低剂量聚乙二醇化干扰素与标准高剂量聚乙二醇化干扰素联合利巴韦林治疗基因型3的慢性丙型肝炎的比较：印度的经验。
3. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial (vol 384, pg 414, 2014) [J] . Manns M., Marcellin P., Poordad F. The Lancet . 2016,第10030期

机译：Simeprevir与聚乙二醇干扰素α2a或2b联合利巴韦林在未接受治疗的慢性丙型肝炎病毒基因型1感染患者中（QUEST-2）：一项随机，双盲，安慰剂对照的3期临床试验（第384卷，第414页，2014年））
4. Studies of Therapy with Thymosin α 1 in Combination with Pegylated Interferon α2a and Ribavirin in Nonresponder Patients with Chronic Hepatitis C [C] . ROBERTO CAMERINI, ALESSIA CIANCIO, ALFONSO DE ROSA, International Symposiumn on Thymosins in Health and Disease; 20070321-24; Washington,DC(US) . 2007

机译：胸腺素α1联合聚乙二醇化干扰素α2a和利巴韦林治疗慢性丙型肝炎无反应者的研究
5. The meaning of adherence among veterans receiving pegylated interferon and ribavirin antiviral treatment for chronic hepatitis C. [D] . Phillips, Frances Hinshaw. 2011

机译：接受聚乙二醇干扰素和利巴韦林抗病毒治疗的慢性丙型肝炎退伍军人依从性的含义。
6. Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-naïve patients with chronic hepatitis C genotype 1 [O] . M Palmer, R Rubin, V Rustgi -1

机译：随机临床试验：在未接受过治疗的慢性丙型肝炎基因型患者中在开始聚乙二醇化干扰素与标准联合治疗之前先加用他巴韦林
7. PIN50 The Clinical Efficacy and Cost-Effectiveness of Boceprevir in Combination with Pegylated Interferon- Alfa and Ribavirin for the Treatment of Genotype 1 Chronic Hepatitis C Patients: A Within Trial Analysis from the Perspective of the Scottish National Health Service (NHS) [O] . Nikoglou E., Humphreys S., El khoury A., 2011

机译：PIN50 Boceprevir与聚乙二醇干扰素-Alfa和Ribavirin联合治疗基因型1型慢性丙型肝炎患者的临床疗效和成本效益：从苏格兰国家卫生服务局（NHS）的角度进行试验分析

Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-na?ve patients with chronic hepatitis C genotype 1

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