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首页> 外文期刊>American journal of applied sciences >THE BENEFICIAL EFFECT OF ASIATICOSIDE ON EXPERIMENTAL NEUROPATHY IN DIABETIC RATS
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THE BENEFICIAL EFFECT OF ASIATICOSIDE ON EXPERIMENTAL NEUROPATHY IN DIABETIC RATS

机译：阿糖胺甙对糖尿病大鼠实验性神经病的有益作用

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Though diabetic neuropathy produces high impact on quality of life, annual cost and morbidities, the therapeutic efficacy is still not in a satisfaction level. Based on the crucial role of oxidative stress on the pathophysiology of diabetic neuropathy and the improvement of this condition induced by antioxidant, we hypothesized that asiaticoside, a substance possessing antioxidant activity, could provide beneficial effect. Therefore, we aimed to determine the effect of asiaticoside on the recovery of sciatic nerve in experimental neuropathy in diabetic rats. Young adult male Wistar rats at 8 weeks old, weighing approximate 180-220 g, were orally given asiaticoside at doses of 0.1 and 1 mg kg~(-1) BW at a period of 5 days before and 3 weeks after sciatic nerve crush injury. Motor and sensory functions were observed every 3 day until the end of the experiment by using Deminacelli method, walking pattern, muscle power and foot reflex withdrawal test, respectively. Our results showed that both doses of asiaticoside could significantly reverse the enhanced withdrawal threshold intensity elicited by electrical stimuli. However, the rats received asiaticoside at dose of 1 mg kg~(-1) BW provided optimum benefit. However, no other significant effects were observed. Asiaticoside administration in an experimental model of neuropathy in diabetic rats mitigates some functional impairment of sciatic nerve. Though our data show only the beneficial effect of asiaticoside on the foot withdrawal reflex, it is very much important because it involve the protective mechanism against painful stimuli. Therefore, it is worth for further investigation in order to confirm the improvement of sensori-motor functions and determined the both therapeutic window and possible underlying mechanism.
机译：尽管糖尿病性神经病对生活质量，年成本和发病率产生很大影响，但治疗效果仍未达到令人满意的水平。基于氧化应激在糖尿病神经病变的病理生理中的关键作用以及抗氧化剂引起的这种状况的改善，我们推测具有抗氧化活性的积雪草苷可以提供有益的作用。因此，我们旨在确定积雪草苷对糖尿病大鼠实验性神经病中坐骨神经恢复的影响。坐骨神经挤压伤前5天和3周后，将重约180-220 g的年轻成年雄性Wistar大鼠体重约180-220 g，口服去甲积子甙，剂量为0.1和1 mg kg〜（-1）BW。 。每三天观察一次运动和感觉功能，直到实验结束为止，分别使用Deminacelli方法，步行模式，肌肉力量和足反射撤回试验进行观察。我们的结果表明，两种剂量的积雪草苷都可以显着逆转电刺激引起的戒断阈值强度的增强。然而，大鼠接受积雪草苷的剂量为1 mg kg〜（-1）BW，提供了最佳的益处。但是，没有观察到其他显着影响。在糖尿病大鼠神经病实验模型中给予积雪草苷可减轻坐骨神经的某些功能损伤。尽管我们的数据仅显示积雪草苷对足部退缩反射有有益作用，但它非常重要，因为它涉及防止疼痛刺激的保护机制。因此，有必要进行进一步的研究以确认感觉运动功能的改善并确定治疗窗口和可能的潜在机制。

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